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1.
Acta Neurochir (Wien) ; 163(2): 561-562, 2021 02.
Article in English | MEDLINE | ID: mdl-33067689
2.
4.
World Neurosurg ; 134: 428-433, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31759153

ABSTRACT

BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant embryonal central nervous system tumor with a poor prognosis. Its occurrence in the pineal region is extremely rare, with only 6 cases in adults reported so far. CASE DESCRIPTION: We report on a puerperal woman with an AT/RT in the pineal region. Total tumor resection was performed. Definitive diagnosis was confirmed by the loss of nuclear INI1/SMARCB1 staining. The patient underwent radiotherapy and chemotherapy with no evidence of recurrence at 31 months after surgery. CONCLUSIONS: This case highlights the importance of immunohistochemistry in the diagnosis of the disease and the importance of an aggressive treatment.


Subject(s)
Brain Neoplasms/pathology , Rhabdoid Tumor/pathology , Teratoma/pathology , Adult , Brain Neoplasms/surgery , Female , Humans , Pineal Gland , Rhabdoid Tumor/surgery , Teratoma/surgery
6.
Acta Neurochir (Wien) ; 158(3): 497, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26782828
7.
Acta Neurochir (Wien) ; 158(3): 489-90, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26659472
9.
Case Rep Surg ; 2014: 834537, 2014.
Article in English | MEDLINE | ID: mdl-25386379

ABSTRACT

Sacral giant cell tumors are rare neoplasms, histologically benign but potentially very aggressive due to the difficulty in achieving a complete resection, their high recurrence rate, and metastization capability. Although many treatment options have been proposed, en bloc excision with tumor-free margins seems to be the most effective, being associated with long term tumor control, improved outcome, and potential cure. An exemplifying case of a 29-year-old female with progressive complaints of pain and paresthesias in the sacral and perianal regions, constipation, and weight loss for 6 months is presented. The surgical technique for en bloc excision of a large sacral giant cell tumor through a modified Kraske procedure with mid-sacrectomy and coccygectomy is described. Complete resection with wide tumor-free margins was achieved. At 5 years of follow-up the patient is neurologically intact, without evidence of local recurrence on imaging studies. A multidisciplinary surgical procedure is mandatory to completely remove sacral tumors. In the particular case of giant cell tumors, it allows minimizing local recurrence preserving neurovascular function, through a single dorsal and definitive approach.

10.
Case Rep Med ; 2014: 739862, 2014.
Article in English | MEDLINE | ID: mdl-25328530

ABSTRACT

Introduction. Spinal schwannomas are benign nerve sheath tumors. Completely extradural schwannomas of the lumbar spine are extremely rare lesions, accounting for only 0,7-4,2% of all spinal NSTs. Standard open approaches have been used to treat these tumors, requiring extensive muscle dissection, laminectomy, radical foraminotomy, and facetectomy. In this paper the authors present the case of a minimally invasive resection of a completely extradural schwannoma. Operative technique literature review is presented. Material & Methods. A 50-year-old woman presented with progressive complains of chronic right leg pain and paresthesia. The magnetic resonance imaging revealed a giant well-encapsulated dumbbell-shaped extradural lesion at the L3-L4 level. The patient underwent a minimally invasive gross total resection of the tumor using a tubular expandable retractor system. Results. The patient had complete resolution of radiculopathy in the immediate postoperative period and she was discharged home, neurologically intact, on the second postoperative day. Postoperative MRI demonstrated no evidence of residual tumor. At latest follow-up (18 months) the patient remains asymptomatic. Conclusion. Although challenging, this minimally invasive procedure is safe and effective, being an appropriate alternative, with many potential advantages, to the open approach.

16.
Peptides ; 25(12): 2105-14, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15572198

ABSTRACT

The aim of the present study was to compare in man the innervation pattern and the functional responses to neuronal messengers in medium sized lenticulostriate and branches of the posterior cerebral arteries (PCA). The majority of the nerve fibers found were sympathetic and displayed specific immunoreactivity for tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Only few nerve fibers displayed vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity. In both arteries, the contractions induced by noradrenaline (NA), NPY and 5-hydroxytryptamine (5-HT) and the relaxant responses induced by acetylcholine (ACh), VIP and pituitary adenylate cyclase activating peptide-27 (PACAP) as well as CGRP and SP were compared in vitro. In conclusion, there was no major difference in innervation pattern or vasomotor sensitivity (pEC50 and pIC50 values) between the two vessels. However, the general pattern indicates stronger vasomotor responses (Emax and Imax) in the PCA branches as compared to the lenticulostriate arteries which may lend support for the clinical observation of a difference in stroke expression between the two vascular areas.


Subject(s)
Basal Ganglia/blood supply , Cerebral Arteries/innervation , Posterior Cerebral Artery/innervation , Vasomotor System/physiology , Acetylcholine/pharmacology , Humans , Immunohistochemistry , Muscle Contraction/drug effects , Muscle Relaxation/drug effects , Nerve Growth Factors/pharmacology , Neuropeptide Y/pharmacology , Neuropeptides/pharmacology , Neurotransmitter Agents/pharmacology , Norepinephrine/pharmacology , Parasympathetic Nervous System/physiology , Pituitary Adenylate Cyclase-Activating Polypeptide , Serotonin/pharmacology , Stroke/physiopathology , Vasoactive Intestinal Peptide/pharmacology
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