Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans.

Prior longitudinal work suggests that blood pressure (BP) reactivity to the cold pressor test (CPT) helps predict hypertension; yet the impact of age and sex on hemodynamic and neural responsiveness to CPT remains equivocal. Forty-three young (21 ± 1yr, means ± SE) men (YM, n = 20) and women (YW, n = 23) and 16 older (60 ± 1yr) men (OM, n = 9) and women (OW, n = 7) participated in an experimental visit where continuous BP (finger plethysmography) and muscle sympathetic nerve activity (MSNA; microneurography) were recorded during a 3- to 5-min baseline and 2-min CPT. Baseline mean arterial pressure (MAP) was greater in OM than in YM (92 ± 4 vs. 77 ± 1 mmHg, P < 0.01), but similar in women (P = 0.12). Baseline MSNA incidence was greater in OM [69 ± 6 bursts/100 heartbeats (hb)] than in OW (44 ± 7 bursts/100 hb, P = 0.02) and lower in young adults (YM: 17 ± 3 vs. YW: 16 ± 2 bursts/100 hb, P < 0.01), but similar across the sexes (P = 0.83). However, when exposed to the CPT, MSNA increased more rapidly in OW (Δ43 ± 6 bursts/100 hb; group × time, P = 0.01) compared with OM (Δ15 ± 3 bursts/100 hb) but was not different between YW (Δ30 ± 3 bursts/100 hb) and YM (Δ33 ± 4 bursts/100 hb, P = 1.0). There were no differences in MAP with CPT between groups (group × time, P = 0.33). These findings suggest that OW demonstrate a more rapid initial rise in MSNA responsiveness to a CPT compared with OM. This greater sympathetic reactivity in OW may be a contributing mechanism to the increased hypertension risk in postmenopausal women.

Multiple concurrent visual-motor mappings: implications for models of adaptation.

Previous research on adaptation to visual-motor rearrangement suggests that the central nervous system represents accurately only 1 visual-motor mapping at a time. This idea was examined in 3 experiments where subjects tracked a moving target under repeated alternations between 2 initially interfering mappings (the "normal" mapping characteristic of computer input devices and a 108 degree rotation of the normal mapping). Alternation between the 2 mappings led to significant reduction in error under the rotated mapping and significant reduction in the adaptation aftereffect ordinarily caused by switching between mappings. Color as a discriminative cue, interference versus decay in adaptation aftereffect, and intermanual transfer were also examined. The results reveal a capacity for multiple concurrent visual-motor mappings, possibly controlled by a parametric process near the motor output stage of processing.

A vector-sum process produces curved aiming paths under rotated visual-motor mappings.

Under a 90 degrees rotation of motor space relative to visual space, human two-dimensional aiming movements frequently take the form of smooth arcs such as spirals and semi-circles. A time-independent differential equation explains this tendency in terms of a rotation-induced vector field made up, at each point in the two-dimensional space, of two input vectors. One vector represents a visual error signal and the other represents a motor error signal. A trajectory's instantaneous direction of movement at each point can be described as the resultant of the two vectors. This mathematical formulation incorporates plausible visual-motor mechanisms and, when expressed in polar coordinates, leads to a new method for analyzing the spatial properties of movements (i.e., movement paths). Plots of the angle between the resultant and the target vector (phi) against distance from the target (r, in the polar representation) summarize the arc-shaped movement paths as a simple relation that can be analyzed statistically with respect to properties such as monotonicity. The polar representation is a plausible representation of visually-guided movements, with the visual error vector functioning as an objective function relative to which behavior is optimized. We extend the model and the r, phi movement path analysis to non-90 degrees rotations, and we find that the model predicts an observed qualitative shift in behavior for rotations greater than 90 degrees. It also predicts qualitatively different path shapes observed under visual-motor reflections.

Aiming error under transformed spatial mappings suggests a structure for visual-motor maps.

Transformed spatial mappings were used to perturb normal visual-motor processes and reveal the structure of internal spatial representations used by the motor control system. In a 2-D discrete aiming task performed under rotated visual-motor mappings, the pattern of spatial movement error was the same for all Ss: peak error between 90 degrees and 135 degrees of rotation and low error for 180 degrees rotation. A two-component spatial representation, based on oriented bidirectional movement axes plus direction of travel along such axes, is hypothesized. Observed reversals of movement direction under rotations greater than 90 degrees are consistent with the hypothesized structure. Aiming error under reflections, unlike rotations, depended on direction of movement relative to the axis of reflection (see Cunningham & Pavel, in press). Reaction time and movement time effects were observed, but a speed-accuracy tradeoff was found only for rotations for which the direction-reversal strategy could be used. Finally, adaptation to rotation operates at all target locations equally but does not alter the relative difficulty of different rotations. Structural properties of the representation are invariant under learning.