[Gossypiboma in neurosurgery. Case report and literature review]. / Gossypiboma en Neurocirugía. Descripción de un caso y revisión de la literatura.

The terms gossypiboma, textiloma or retained foreign objects are medical terms used to describe textile elements that are left intentionally or accidentally in the operative site and generate a reaction to foreign objects. It can be avoided when preventive measures are taken during surgery. Gossypibomas are rare in surgery of the central nervous system. They are more frequent in thoracic and abdominal surgeries. Depending on their location they can present with complications and symptoms or they may remain undetected for many years. In this article we want to present a case of a spinal asymptomatic gossypiboma in a patient who was operated on 15 years ago for a lumbar disectomy. We will review the literature on the implications of these lesions on the neurosurgical field.

Gossypiboma en Neurocirugía. Descripción de un caso y revisión de la literatura / Gossypiboma in Neurosurgery. Case report and literature review

Los términos gossypiboma, textiloma o cuerpo extrañotextil retenido son términos médicos usados paradescribir elementos quirúrgicos textiles que intencionalo accidentalmente son dejados sobre el lecho quirúrgico,generando una reacción a cuerpo extraño. Es unapatología prevenible siempre y cuando se tomen algunasmedidas durante la cirugía. Los gossypiboma sonpoco frecuentes a nivel del sistema nervioso central. Sonmás frecuentes en las cirugías torácicas o abdominales.Dependiendo de su localización y su comportamiento,éstos pueden presentar complicaciones y sintomatologíao pueden permanecer silentes por muchos años.En este trabajo se presenta un caso de un gossypibomaparaespinal asintomático en una pacienteoperada 15 años antes para una discectomía lumbar.Se hace además una revisión de la literatura y secomenta acerca de la implicación de estas lesiones enneurocirugía (AU)

The terms gossypiboma, textiloma or retainedforeign objects are medical terms used to describe textileelements that are left intentionally or accidentallyin the operative site and generate a reaction to foreignobjects. It can be avoided when preventive measuresare taken during surgery. Gossypibomas are rare insurgery of the central nervous system. They are morefrequent in thoracic and abdominal surgeries. Dependingon their location they can present with complications and symptoms or they may remain undetected formany years.In this article we want to present a case of a spinalasymptomatic gossypiboma in a patient who was operatedon 15 years ago for a lumbar disectomy. We willreview the literature on the implications of these lesionson the neurosurgical field (AU)

Synthesis and angiotensin II receptor antagonist activity of C-linked pyrazole derivatives.

The synthesis and pharmacological activity of new nonpeptide angiotensin II (AII) receptor antagonists are presented. These 5-O-substituted and 5-C-substituted 3-alkylpyrazole derivatives represent a new series of antagonists and have led to the discovery of compounds with potent oral antihypertensive activity in a renal artery-ligated rat model. In vitro, they displayed a high affinity for rat adrenal AII receptors. In vivo structure-activity relationship study has shown the importance of the 4-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl moiety for oral activity and the critical role of alkyl substituents at the 1- or 2-position. In the case of oral administration, 5-C derivatives were found to be, on the whole, more potent than 5-O derivatives. UP 221-78, 5-hydroxymethyl-3-n-propyl-1-(2,2,2-trifluoroethyl)-4- [[2'-(1H-tetrazol-5-yl)biphenyl-4-]methyl]-1H-pyrazole (79), displayed equivalent antihypertensive activity to the well known antagonist Losartan at 3 mg/kg p.o. in renal artery-ligated rats, with maximal decreases in mean arterial pressure of 60 and 63 mmHg for Losartan and UP 221-78, respectively.

Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.

The synthesis and pharmacological activity of new nonpeptide angiotensin II (AII) receptor antagonists are presented. These [1,2,4]-triazolo[1,5-c]pyrimidine and 1,2,4-triazolo[4,3-c]pyrimidine derivatives represent a new class of bicyclic antagonists that produced a potent, oral antihypertensive activity in the renal artery-ligated rat model. In vitro, they displayed a high affinity for rat adrenal AII receptors and were found to be specific for the AT1 receptor subtype. A SAR study has shown the importance of the 8-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl for oral activity and the critical role of alkyl substituents at 5- and 7-positions. No significant differences were found between the [1,5-c] and [4,3-c]series. UP 269-6 (5-methyl-7-n-propyl-8-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl ]- [1,2,4]-triazolo[1,5-c]pyrimidin-2(3H)-one, derivative 29) was selected as the lead compound. It was shown to be a highly potent antihypertensive derivative (decrease in mean arterial pressure of 39.6 +/- 7.2 mmHg at 1 mg/kg po in renal artery-ligated rat) with a long duration of action which displayed a high affinity for adrenal AII receptors with a marked selectivity for the AT1 receptor subtype (Ki AT1 = 24 nM; Ki AT2 = 79,200 nM). This compound is currently undergoing extensive pharmacological and clinical development.