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Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis.
Laurà, M; Gregson, N A; Curmi, Y; Hughes, R A C.
J Neuroimmunol ; 133(1-2): 56-9, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12446008

ABSTRACT

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.


Subject(s)
Growth Inhibitors/pharmacology , Guillain-Barre Syndrome/drug therapy , Interleukin-6 , Lymphokines/pharmacology , Neuritis, Autoimmune, Experimental/drug therapy , Spinal Nerve Roots/drug effects , Animals , Axons/drug effects , Axons/immunology , Axons/pathology , Body Weight/drug effects , Body Weight/immunology , Cauda Equina/drug effects , Cauda Equina/immunology , Cauda Equina/pathology , Disease Models, Animal , Dose-Response Relationship, Drug , Growth Inhibitors/therapeutic use , Leukemia Inhibitory Factor , Lymphokines/therapeutic use , Myelin Sheath/drug effects , Myelin Sheath/immunology , Myelin Sheath/pathology , Neuritis, Autoimmune, Experimental/pathology , Neuritis, Autoimmune, Experimental/physiopathology , Rats , Sciatic Nerve/drug effects , Sciatic Nerve/immunology , Sciatic Nerve/pathology , Spinal Nerve Roots/immunology , Spinal Nerve Roots/pathology , Treatment Outcome , Wallerian Degeneration/drug therapy , Wallerian Degeneration/immunology , Wallerian Degeneration/pathology
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