Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters









Database
Language
Publication year range
1.
The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists.
Reid, Mark; Carlyle, Ian; Caulfield, Wilson L; Clarkson, Tom R; Cusick, Fiona; Epemolu, Ola; Gilfillan, Robert; Goodwin, Richard; Jaap, David; O'Donnell, Elise C; Presland, Jeremy; Rankovic, Zoran; Spinks, Daniel; Spinks, Gayle; Thomson, Anne M; Thomson, Fiona; Strain, James; Wishart, Grant.
Bioorg Med Chem Lett ; 20(12): 3713-6, 2010 Jun 15.
Article in English | MEDLINE | ID: mdl-20471831

ABSTRACT

Antagonists of the 5-HT(6) receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer's disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides-a novel chemotype of 5-HT(6) antagonists.


Subject(s)
Amides/chemistry , Indoles/chemistry , Receptors, Serotonin/drug effects , Serotonin Receptor Agonists/chemical synthesis , Amides/pharmacology , Animals , Biological Availability , Drug Discovery , Humans , Indoles/pharmacology , Male , Microsomes , Pharmacokinetics , Rats , Rats, Wistar , Serotonin Receptor Agonists/chemistry , Structure-Activity Relationship
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL