ABSTRACT
BD-1158 is a new 1,4 benzodiazepine derivative. The purpose of the present experiments was to test the spontaneous behaviour (typical of a rabbit) after administration of BD-1158 and thus to define the activity and side effects of this substance under physiological conditions. The experiments were performed for 3 subsequent days in a group of 10 rabbits. On the first day spontaneous behaviour was tested. On the second day 1 ml of 1% starch solution was administered intraperitoneally. On the third day BD-1158 was administered intraperitoneally at a dose 10 mg/kg diluted in 1% starch solution up to 1 ml, 35-40 minutes before the beginning of the experiment. Six phases of behaviour were estimated. It was concluded that BD-1158 has a strong anxiolytic and sedative effect, decreases the state of animal's attention, water and food uptake.
Subject(s)
Anti-Anxiety Agents/pharmacology , Behavior, Animal/drug effects , Benzodiazepines/pharmacology , Animals , Drinking/drug effects , Eating/drug effects , Male , Orientation/drug effects , RabbitsABSTRACT
The influence and the role of corticotrophin analogue 4-10 on the rabbits' behaviour in spontaneous conditions was analysed. The data analysis indicated that analogue 4-10 with modified aminoacid sequence in 8, 9, 10 positions significantly influenced the behavioural changes in the general model of behaviour. The 4-10 corticotrophin derivative caused the suppression of aggression, considerably reduced the tension and orientation-cognition reactions, however, it prolonged comfort and grooming significantly. This may prove the noticeable reaction of analogue 4-10 in modification of behavioural pattern, which was expressed by restraining the reaction of stressogenic character with simultaneous attenuation and prolongation of appetite reactions.
