ABSTRACT
Due to present unavailability of Alkiron the authors tried to substitute it by Carbimazole in atherogenic diet aimed at inducing advanced atherosclerosis in rats. Carbimazole proved to be entirely ineffective in this respect and thus the thiouracil derivatives cannot be substituted by it.
Subject(s)
Arteriosclerosis/chemically induced , Carbimazole/administration & dosage , Diet, Atherogenic , Methylthiouracil/administration & dosage , Animals , Aorta/pathology , Arteriosclerosis/blood , Arteriosclerosis/pathology , Female , Lipids/blood , RatsABSTRACT
Due to present unavailability of Alkiron the authors tried to substitute it by Carbimazole in atherogenic diet aimed at inducing advanced atherosclerosis in rats. Carbimazole proved to be entirely ineffective in this respect and thus the thiouracil derivatives cannot be substituted by it.
Subject(s)
Carbimazole/administration & dosage , Diet, Atherogenic , Methylthiouracil/administration & dosage , Animals , Carbimazole/pharmacology , Cholesterol/blood , Female , Methylthiouracil/pharmacology , RatsABSTRACT
Postlathyric aortic fibroelastosis was produced in rats with the aid of low-percentage fetal lathyrism. Subsequently the rats were kept on an atherogenic regimen for one year, and at the end of that period the aortas were studied to detect the relation of postlathyric alterations to the experimental atherosclerotic lesions. In the ascending aorta and the arch the fibroelastosis neither enhanced nor suppressed the development of mixed atherosclerotic plaques. In contrast, fibroelastosis of the thoracic and abdominal aorta usually causing a slight tunnel-shaped stenosis of the affected segment significantly reduced the development of intimal lipoidosis. The present experiment permitted to identify a new postlathyric lesion, namely sac-shaped microaneurysms situated at the sites of origin of lumbar arteries. Despite the fact that otherwise virtually the only lesion developing in the abdominal aorta was intimal lipoidosis, the aneurysms were filled up with mixed atheromatous masses. The above postlathyric vascular lesion appeared to significantly support the local development of atherosclerosis. The results presented have been discussed in view of the some recent facts stressing the indisputable importance of haemodynamic factors for the localization and development of atherosclerosis.
Subject(s)
Aortic Diseases/etiology , Arteriosclerosis/etiology , Lathyrism/complications , Animals , Aortic Diseases/pathology , Arteriosclerosis/pathology , Diet, Atherogenic , Female , Male , RatsSubject(s)
Arteriosclerosis/blood , Cholesterol/blood , Diet, Atherogenic , Animals , Aorta/metabolism , Arteriosclerosis/metabolism , Lipid Metabolism , Male , RatsABSTRACT
Regression of experimental atherosclerotic lesions of rat heart valves was studied in a long-term experiment. Following a period of regression of 12 months duration, the thick superficial layers of foam cells disappeared completely. Persisting masses of cholesterol crystals did not seem to be accompanied by any cellular proliferation or fibrous reaction. Such cholesterol deposits showed peculiar transparent cystoid areas probably representing local cholesterol dissolution. The structural differences between arterial and valvular plaques can be hypothetically explained by small numbers of smooth muscle cells in the heart valves.
Subject(s)
Arteriosclerosis/pathology , Heart Valves/pathology , Animals , Cholesterol/metabolism , Diet, Atherogenic , Endocardium/pathology , Female , Inclusion Bodies/pathology , Rats , Staining and LabelingSubject(s)
Arteriosclerosis/pathology , Animals , Aorta/pathology , Coronary Vessels/pathology , Female , Heart Valves/pathology , Humans , Male , Rats , Rats, Inbred StrainsABSTRACT
Liver tissue biopsy performed in a man of 44 and another man of 52, who had for long periods of time been using phenacetin-containing analgesics, revealed accumulations of lipofuscin in hepatocytes, in sinoendothelia and in Kupffer's cells. Apart from more frequent destruction of hepatocytes, there were no microscopic or ultrastructural changes suggesting any major liver tissue damage.
Subject(s)
Analgesics/adverse effects , Chemical and Drug Induced Liver Injury , Lipofuscin/metabolism , Pigments, Biological/metabolism , Adult , Humans , Liver/metabolism , Liver/pathology , Liver Diseases/pathology , MaleABSTRACT
Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular topography of atherosclerotic valvular lesions was believed to be primarily due to differences in blood pressure as occurring during cardiac performance. Histologically, there was a striking contrast between the uniform composition of atheromatous plaques as found on the valves and the variability in composition of aortic atheromas.
