Subject(s)
Meningitis, Viral/etiology , Mumps/complications , Adolescent , Antibodies, Viral/isolation & purification , Child , Humans , Immunoglobulin A/isolation & purification , Immunoglobulin G/isolation & purification , Immunoglobulin M/isolation & purification , Meningitis, Viral/diagnosis , Mumps virus/immunology , Time FactorsSubject(s)
Encephalitis/microbiology , Facial Paralysis/microbiology , Meningitis, Viral/microbiology , Virus Diseases/microbiology , Adenovirus Infections, Human/microbiology , Adolescent , Animals , Chick Embryo , Child , Child, Preschool , Enterovirus Infections/microbiology , Female , Humans , In Vitro Techniques , Male , Orthomyxoviridae Infections/microbiology , Respirovirus Infections/microbiology , Rubella/microbiology , Virus Cultivation/methodsABSTRACT
In CSF of patients with acute aseptic meningitis (AAM) an increase in the percentage of total and active T lymphocytes was observed, whereas in SSPE a decrease in T cells was noted. In SSPE there was the increase in the relative number of lymphocytes bearing "avid" FcIgG receptor and decrease in alpha-naphthyl nonspecific esterase-positive cells, but in AAM the cell proportions were not disturbed. The changes in the peripheral blood lymphocytes subsets were less evident. The results seem to suggest that in AAM there is a strong T response in CSF with well preserved proportions of T-cell subsets, while in SSPE a low T-cell level may be accompanied by disturbances in T-cell function.
Subject(s)
Lymphocytes/classification , Meningitis, Aseptic/cerebrospinal fluid , Meningitis/cerebrospinal fluid , Subacute Sclerosing Panencephalitis/cerebrospinal fluid , Acute Disease , Adolescent , Antibody Affinity , Cerebrospinal Fluid/cytology , Cerebrospinal Fluid/immunology , Child , Child, Preschool , Humans , Immunoglobulin Fc Fragments/immunology , Immunoglobulin G/immunology , Infant , Lymphocytes/immunology , Meningitis, Aseptic/immunology , Receptors, Immunologic/immunology , Rosette Formation , Subacute Sclerosing Panencephalitis/immunology , T-Lymphocytes/immunology , T-Lymphocytes, Regulatory/analysisABSTRACT
Lymphocyte subpopulations were evaluated in the cerebrospinal fluid and peripheral blood in 22 patients in the initial stage of aseptic meningitis and during convalescence. In the acute stage of the disease the proportion of lymphocytes T, including their active forms, was increased, during convalescence a further significant rise was observed in the subpopulation of lymphocytes T with a fall of the proportion of lymphocytes bearing the high "avid" Fc IgG receptor. In patients with acute meningitis and during convalescence a rise was observed in the proportion of lymphocytes T in the peripheral blood. In the acute stage of the disease the number of lymphocytes with a high binding ability of the Fc receptor was decreased. Changes in lymphocytes subpopulations in aseptic meningitis suggest mobilization of lymphocytes engaged in the cell-mediated immune response.
Subject(s)
Coxsackievirus Infections/immunology , Meningitis, Viral/immunology , T-Lymphocytes/immunology , Adolescent , Cerebrospinal Fluid/cytology , Child , Child, Preschool , Coxsackievirus Infections/cerebrospinal fluid , Cytotoxicity, Immunologic , Enterovirus B, Human , Humans , Infant , Leukocyte Count , Leukocytosis/etiology , Meningitis, Viral/cerebrospinal fluidABSTRACT
The influence of CSF on the active and total E-rosette test with peripheral blood (PB) lymphocytes of 12 children with aseptic meningitis (AM) was estimated. The control group included 10 children with convulsive fever. An increase in active and total T cells after incubation with CSF was observed in AM. This phenomenon might in part explain the higher proportion of T cells appearing in the CSF during aseptic meningitis. No changes were observed in the control group.
