ABSTRACT
PURPOSE: Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade and common myopia, respectively. This study was conducted to investigate whether these collagen genes are associated and/or genetically linked with myopia in large Caucasian family datasets. METHODS: High-grade myopia was defined as Subject(s)
Chromosomes, Human, Pair 12/genetics
, Collagen Type II/genetics
, Collagen Type I/genetics
, Genetic Linkage
, Genetic Predisposition to Disease
, Myopia/genetics
, Polymorphism, Single Nucleotide
, Adult
, Collagen Type I, alpha 1 Chain
, Female
, Genetic Markers
, Genotype
, Humans
, Male
