ABSTRACT
Most neonatal Herpes-simplex-virus infections are the result of virus acquisition during passage through the birth canal. Transplacental transmission of HSV is seldom. The infection is mostly localized at the skin, eyes and central nervous system. The disseminated HSV-infection represents as the most severe clinical picture. It is reported about meningoencephalitis caused by HSV in 3 infants in the first weeks of life. The therapeutic success of antiviral chemotherapeutics depends very much on their application at an early stage of the disease, which can be recognized by cerebral sonography and detection of IgM-antibodies against HSV.
Subject(s)
Herpes Simplex/diagnosis , Meningoencephalitis/diagnosis , Acyclovir/therapeutic use , Antibodies, Viral/cerebrospinal fluid , Brain/pathology , Echoencephalography , Female , Herpes Simplex/drug therapy , Humans , Male , Meningoencephalitis/drug therapy , Simplexvirus/immunology , Tomography, X-Ray ComputedABSTRACT
821 patients have been examined with regard to the presence of B streptococci. We isolated B streptococci in 5.4 per cent in gynaecologic outpatients, in 0.4 per cent in 236 pregnant women and in 5.8 per cent in 156 newborns. From 78 to these newborns we were able to examine the mothers during their stay in the delivery room, too. Only in one parturient and her newborn we could detect B streptococci. In three B streptococci positive newborns is was not possible to prove this germ in the vaginal content of their mothers. Clinical symptoms were not present in no case. Antibiograms were not peculiar.
Subject(s)
Pregnancy Complications, Infectious/microbiology , Streptococcal Infections/microbiology , Vaginitis/microbiology , Bacteriological Techniques , Drug Resistance, Microbial , Female , Humans , Infant, Newborn , Pregnancy , Streptococcus agalactiae/isolation & purificationABSTRACT
The in vitro stimulation of lymphocytes from 15 healty adult donors by 5 different stains of CMV resulted in a positive stimulation ratio of lymphocytes from CMV seropositive donors with each of the 5 different strains. Differences in the absolute strength of the response was observed among the 5 strains for each individual, but we concluded that the use of antigen prepared with 1 strain of CMV is sufficient to obtain a positive or negative result. A maximum value for the in vitro lymphocyte stimulation test, however, will only be obtained using different antigen concentrations from several different CMV strains simultaneously.
