[Results of ambulatory mono- and combined interferon therapy in advanced kidney tumors]. / Ambulanter végzett interferon mono- és kombinációs terápia eredménye elórehaladott vesedaganat esetén.

The authors summarized their experiences during interferon alpha 2b treatment for RCC of advanced stage with special respect to the changes in general condition of patients. Since 1991 ambulantory interferon treatment was carried out on 35 patients. An account is given about the observations on treatment of 31 patients from this a group. After setting up three treatment-groups 4 patients received monotherapy, alpha interferon 2b subcutaneous injection in the first 3 days of the week, in 6-10 mill.i.u.dose. In combination with alpha interferon treatment 7 patients received a daily dose of 500 mg of medroxyprogesteron acetate, while in 20 cases 0.1 mg/body weight vinblastin infusion was given every three weeks with combination of alpha interferon treatment. In four cases complete (CR), in 5 cases partial remission was achieved (PR) while 10 patient remained in an unchanged state (NC). In 12 cases progression can be experienced. Ten patients died during the observation period. The clinical response time was 15 months (3-26), the remission period was in an average 9 months (5-14) and the remission rate (CR + PR) was 29% (31/9). According to the authors, the interferon treatment, despite its significant side effects, can be considered important and remarkable treatment.

Urological tuberculosis mimicking bladder tumour.

A total of 8 patients have been treated in the recent 10 years in whom urogenital tuberculosis simulated the picture of bladder tumour. This occurred in 3% of overall patients with urogenital tuberculosis, i.e. primary diagnosis proved to be erroneous in such percentage of them. The course of the disease of 2 patients is reviewed in detail. In order to establish the differential diagnosis between the two diseases, the importance of bladder biopsy following polycystography is pointed out.

A new approach to the treatment of polycystic kidneys.

Maximum conservativism was the watchword up to 1979 in dealing with polycystic disease. In the period 1979 to 1985 a total of 45 patients were subjected to 80 instances of polycystic resection whereby larger cysts were removed by excision, smaller ones by ignipuncture, with particular attention to extirpation of the perihilar cysts. Post-operative incidence of hypertension dropped from 33 to 3%. The method described is rated as one of the feasible expedients to deal with polycystic disease in the early compensated stage.

[Primary carcinomas of the scrotum--5 cases]. / Uber die primären Karzinome des Skrotums--5 Fälle.

Etiology, diagnostic difficulties and clinical feature of the scrotal carcinomata are described. In the course of 10 years 5 cases were observed. The patients at stage T3N2M0-1 survived still 4 to 8 months after operation, while the patients at stage T1 are all still alive. The significance of the early diagnosis is emphasized, in order to prolong the survival time.

Organ-preserving surgery in kidney tumours.

After a survey of the international literature on organ-preserving surgery in kidney tumours, a surgical material of 12 cases is presented, in which a mean survival of 51 months has been attained. In similar cases medical treatment gave survivals of 7 months only. The factors affecting the survivals are analysed and resection in stage T1-2 is advocated on these grounds. Organ-preserving surgery is regarded as justified in stage T1N0M0, even if the other kidney is intact. The decisive importance of appropriate selection of the patients and of a meticulous surgical technique is emphasized.

[A swallowed needle found in the kidney pelvis]. / Uber eine peroral ins Nierenhohlsystem gelangte Sacknadel.

The case of a young female patient is discussed. The authors removed out of the renal hollow system of this patient a needle. The foreign body passed perorally into the renal pelvis after perforation of the duodenum. There the thicker end of the needle was encrusted; a pyelonephrosis, then a septic condition developed. After removal of the needle the kidney operated on showed a good function.

Bilateral testicular tumours.

After discussing the frequency of bilateral testicular tumours, attention is drawn to their rising incidence. In the 10 year period 1967 to 1976, three patients with bilateral testicular tumour were treated at the Department of Urology of the University Medical School of Pécs. Two had successively appearing bilateral seminoma and embryonal carcinoma, in the third patient simultaneously a malignant lymphoma appeared. As regards the question whether bilateral testicular tumours are two independent primary tumours or one is a metastastatic growth, presence of two primary tumours is assumed. The special features of therapy and prognosis are discussed.