ABSTRACT
In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS.
Subject(s)
Motor Neuron Disease/diagnosis , Adolescent , Adult , Age Distribution , Aged , Amyotrophic Lateral Sclerosis/diagnosis , Brazil , Bulbar Palsy, Progressive/diagnosis , Diagnosis, Differential , Female , Hospitals, University , Humans , Male , Middle Aged , Muscular Atrophy, Spinal/diagnosis , Retrospective Studies , Risk FactorsABSTRACT
We report on the preliminary clinical and electrophysiological aspects of an in-patient possibly presenting epilepsia partialis continua (Koshevnikov). We discuss the different etiologies and emphasize on the possible idiopathic form in this case.
Subject(s)
Epilepsia Partialis Continua/diagnosis , Adult , Epilepsia Partialis Continua/etiology , Epilepsia Partialis Continua/physiopathology , Female , HumansABSTRACT
With the purpose of studying data on spontaneous customary changes in diabetic rats, we induced diabetes in 28 Wistar rats with streptozotocin. The animals were observed for 27 weeks in an attempt to characterize spontaneous customary changes that could suggest signs of chronic pain. Morphine, as a central-acting potent analgesic and its specific antagonist naloxone, were used. Our results evidenced in the animals a clinical syndrome similar to human diabetes. Long-term customary analysis revealed a significant (p < 0.05) increase of scratching and resting/sleeping behaviors, but diminished motor, eating and grooming customs. Moreover, the thermal tests revealed hyperalgesia in 43% of the animals, what may corroborate the meaning of scratching as a sign of pain. Pharmacological tests with morphine showed a significant (p < 0.05) inhibition of scratch, with concomitant increase of motor and eating activities and diminished rest/sleep capacity. Naloxone antagonized the effects induced by morphine. Such results suggest that these animals exhibit evoked behavior of hyperalgesia and that scratch may possibly be a spontaneous manifestation of chronic pain also in Wistar rats with this experimental model of painful diabetic neuropathy.
Subject(s)
Behavior, Animal , Diabetes Mellitus, Experimental/physiopathology , Diabetic Neuropathies/physiopathology , Animals , Morphine/antagonists & inhibitors , Morphine/therapeutic use , Naloxone/pharmacology , Narcotic Antagonists/pharmacology , Pain/physiopathology , Pruritus/drug therapy , Rats , Rats, WistarABSTRACT
Tropical spastic paraparesis (TSP) is a chronic progressive myelopathy and in most of the cases has a retroviral (HTLV-1) etiology, when it is denominated HTLV-1 associated-mielopathy (HAM/TSP). Around 433 cases of TSP have been described in Northeast and Southeast Brazil. Among these cases, 157 (36.2%) are HTLV-1 positive and 276 (63.7%) are negative. Their mean age is 43.8 years with a slight predominance of females and mulattoes, although white patients are also numerous. Clinically all patients exhibit a spastic paraparesis with variable sphincter and sensory disturbance. Pain and autonomic symptoms seem to be expressive in the HTLV-1 positive HAM/TSP Brazilian patients.
Subject(s)
Paraparesis, Tropical Spastic/etiology , Adult , Brazil , Female , Humans , Male , Paraparesis, Tropical Spastic/cerebrospinal fluid , Paraparesis, Tropical Spastic/diagnosisABSTRACT
As paraparesia espástica tropical (PET) é uma mielopatia crônica progressiva e em muitos casos tem etiologia retroviral (HTLV-1) (MAH/PET). Cerca de 433 casos de PET têm sido descritos no Nordeste e Sudeste do Brasil, dos quais 157 (36,2 por cento) säo HTLV-1 positivos e 276 (63,7 por cento) Säo negativos. A média de idade dos pacientes é de 43,8 anos. Ocorre discreto predomínio de mulheres e mulatos, embora haja numerosos pacientes brancos. Clinicamente todos os pacientes exibem uma paraparesia espástica com variável distúrbio sensitivo e esfincteriano. Dor e sintomas autonômicos parecem expressivos nos pacientes brasileiros com MAH/PET HTLV-1 positivos
