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1.
Nutrients ; 13(9)2021 Sep 04.
Article in English | MEDLINE | ID: mdl-34578984

ABSTRACT

Obesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance. Exercise and weight loss are associated with decreased breast cancer recurrence, which may be mediated through reduced insulin levels and improved insulin sensitivity. This is a secondary analysis of the WISER Survivor clinical trial examining the relative effect of exercise, weight loss and combined exercise and weight loss interventions on insulin and insulin resistance. The weight loss and combined intervention groups showed significant reductions in levels of: insulin, C-peptide, homeostatic model assessment 2 (HOMA2) insulin resistance (IR), and HOMA2 beta-cell function (ß) compared to the control group. Independent of intervention group, weight loss of ≥10% was associated with decreased levels of insulin, C-peptide, and HOMA2-IR compared to 0-5% weight loss. Further, the combination of exercise and weight loss was particularly important for breast cancer survivors with clinically abnormal levels of C-peptide.


Subject(s)
Breast Neoplasms/prevention & control , Exercise Therapy/methods , Insulin Resistance , Insulin/blood , Neoplasm Recurrence, Local/prevention & control , Weight Reduction Programs/methods , Blood Glucose/analysis , C-Peptide/blood , Cancer Survivors , Female , Humans , Middle Aged
2.
Chempluschem ; 82(3): 416-422, 2017 Mar.
Article in English | MEDLINE | ID: mdl-31962030

ABSTRACT

Highly faceted superparamagnetic magnetite nanoparticles roughly 11 nm in diameter are readily accessible in the presence of p-phosphonated calix[n]arenes of different ring sizes (n=4, 5 and 6), through the use of a simple co-precipitation technique. In contrast, the larger calix[8]arene affords spherical particles of comparable size. The maximum magnetization is 70-60 emu g-1 , which decreases with increasing size of the calixarene macrocycle, and the evidence indicates that the calixarenes bind to the surface of the nanoparticles via the phosphonate head groups rather than the phenolic oxygen centers. The stabilized nanoparticles show dual functionality: they remove up to 62 % of nitrate nitrogen and 48 % of phosphate from an aqueous effluent after 24 hours at concentrations of only 1 g L-1 of calixarene-coated nanoparticles.

3.
Nanoscale ; 5(7): 2627-31, 2013 Apr 07.
Article in English | MEDLINE | ID: mdl-23440091

ABSTRACT

Composite materials based on superparamagnetic magnetite nanoparticles embedded in polyvinylpyrrolidone (PVP) are generated in a continuous flow vortex fluidic device (VFD). The same device is effective in entrapping microalgal cells within this material, such that the functional cells can be retrieved from aqueous dispersions using an external magnet.


Subject(s)
Cell Separation/methods , Magnetite Nanoparticles/chemistry , Microalgae/cytology , Microfluidic Analytical Techniques/methods , Polymers/chemistry , Microalgae/physiology , Povidone/chemistry
4.
Chem Commun (Camb) ; 47(14): 4123-5, 2011 Apr 14.
Article in English | MEDLINE | ID: mdl-21380418

ABSTRACT

A direct seedless method for the continuous synthesis of gold nanorods has been developed using a sequential rotating tube-narrow channel processing microfluidic configuration, with the stock feed solutions (HAuCl(4)/CTAB/acetylacetone and AgNO(3)/CTAB/carbonate buffer) being stable for weeks.

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