ABSTRACT
Osteopetrosis is a heterogeneous group of heritable conditions in which there is a defect in bone resorption by osteoclasts. It is associated with an increased skeletal mass due to abnormally dense, but brittle, bones. Osteopetrosis varies greatly in severity, and fracture treatment remains a matter of controversy due to altered responses to fixation and the risk of osteomyelitis. The fate of sternotomy in this condition is unknown, and osteopetrosis could represent a situation of 'hostile chest'. Here, the case is described of a patient with osteopetrosis and concomitant symptomatic aortic valve stenosis and coronary artery disease.
Subject(s)
Aortic Valve Stenosis/therapy , Aortic Valve/pathology , Calcinosis/therapy , Cardiac Catheterization/methods , Heart Valve Prosthesis Implantation/methods , Osteopetrosis/complications , Sternotomy , Aortic Valve Stenosis/complications , Aortic Valve Stenosis/diagnosis , Calcinosis/complications , Calcinosis/diagnosis , Contraindications , Coronary Artery Disease/complications , Coronary Artery Disease/diagnosis , Coronary Artery Disease/therapy , Female , Humans , Middle Aged , Osteopetrosis/diagnosis , Percutaneous Coronary Intervention , Risk Assessment , Risk Factors , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Pigmented actinic keratosis and melanoma may exhibit overlapping clinical features, thus representing a diagnostic challenge for dermatologists. Although the differentiation between these two entities is traditionally done by histopathology, dermoscopy has been utilized as a useful additional aid for improving the clinical diagnostic accuracy of such pigmented skin lesions. We report the clinical and dermoscopic features of two pigmented actinic keratoses to discuss the difficulties in their preoperative differential diagnosis.
