Long term antifungal efficacy of silver-zinc zeolite nanoparticles incorporated in two soft denture liners - An in vitro assessment.

Background: There is generally a lack of compliance in patients who report with oral candidiasis, as they are advised to temporarily stop wearing the prosthesis and are prescribed topical antifungals which are generally unpleasant to taste and follow a rigorous schedule. Furthermore, with the alarming evidence of drug resistance, there is a need for an enhanced drug and drug delivery system. The aim of the study was to determine the dose-dependent antifungal efficacy of silver-zinc zeolite nanoparticles (SZZ-NPs) when incorporated in two brands of soft denture liners against Candida albicans. Materials and Methods: A total of 72 samples were made to determine the in vitro antifungal efficacy of SZZ-NPs and fluconazole by measuring the mean inhibition diameter (MID). Two concentrations of SZZ-NPs were compared (0.5%, 2% w/w) with fluconazole 5%w/w which is routinely prescribed. The antifungals were incorporated in two types of commercially available soft denture liners (Visco gel, GC soft denture liner). The MIDs were measured at day 1, day 7, day 15, and day 30. The values obtained (P < 0.001) were analyzed with one-way ANOVA, Tukey's post hoc, and independent t-test. Results: A statistically significant difference (P < 0.001) was noted among all the antifungal agents at all the time intervals tested. The anti-fungal efficacy of SSZ-NPs 2% w/w incorporated in GC soft denture liner was significantly superior (P < 0.001) to all groups tested and it retained its antifungal efficacy even on day 30 (MID: 18.33 ± 2.44). Conclusion: SZZ-NPs 0.5%w/w, 2%w/w, and fluconazole 5%w/w can be incorporated with soft denture liners against C. albicans. Fluconazole 5%w/w is the recommended choice for short-term antifungal efficacy, while SZZ-NPs 2%w/w is recommended when long-term antifungal efficacy is needed. GC soft denture liner was the recommended choice.

Nanomaterials and their application in prosthodontics: A review

Objectives: The objective of this paper is to review the available literature on the novelties and applications of nanomaterials in Prosthodontics. Data and Sources: 125 articles were retrieved which included reviews and studies on various nanomaterials used in Dentistry especially Prosthodontics after Gray literature search, cross references and electronic database search in PubMed, MedLine and Google search using the following key words- Nanomaterials, Nanotechnology, Prosthodontics, Dentistry, Applications Study selection: 74 articles were selected and reviewed as they met the selection criteria. Conclusion: Within the scope of this review, reported literature showed that the emerging science of nanotechnology in Dentistry especially in the field of Prosthodontics has triggered growing interest in the potential applications and benefits compared to the conventional materials in use. The latest research progress on the applications of nanomaterials used in Prosthodontics was reviewed with detailed description, keeping in mind the limitations like challenges faced and the health implications.

Three-dimensional finite element analysis of the stress distribution pattern in a mandibular first molar tooth restored with five different restorative materials.

INTRODUCTION: Badly broken or structurally compromised posterior teeth are frequently associated with crown/root fracture. Numerous restorative materials have been used to fabricate indirect full-coverage restorations for such teeth. This study aims to evaluate and compare the effect of restorative materials on the stress distribution pattern in a mandibular first molar tooth, under varying loading conditions and to compare the stress distribution pattern in five commonly used indirect restorative materials. MATERIALS AND METHODS: Five three-dimensional finite element models representing a mandibular first molar tooth restored with crowns of gold, porcelain fused to metal, composite (Artglass), alumina-based zirconia (In-Ceram Zirconia [ICZ]), and double-layered zirconia-based materials (zirconia core veneered with porcelain, Lava) were constructed, using a Finite Element Analysis Software (ANSYS version 10; ANSYS Inc., Canonsburg, PA, USA). Two loading conditions were applied, simulating maximum bite force of 600 N axially and normal masticatory bite force of 225 N axially and nonaxially. RESULTS: Both all-ceramic crowns allowed the least amount of stress distribution to the surrounding tooth structure. In maximum bite force-simulation test, alumina-based all-ceramic crown displayed the highest von Mises stresses (123.745 MPa). In the masticatory bite force-simulation test, both all-ceramic crowns (122.503-133.13 MPa) displayed the highest von Mises stresses. CONCLUSIONS: ICZ crown displayed the highest peak von Mises stress values under maximum and masticatory bite forces. ICZ and Lava crowns also allowed the least amount of stress distribution to the surrounding tooth structure, which is indicative of a favorable response of the underlying tooth structure to the overlying full-coverage indirect restorative material. These results suggest that ICZ and Lava crowns can be recommended for clinical use in cases of badly damaged teeth.

Association between socio-demographic variables and partial edentulism in the Goan population: an epidemiological study in India.

CONTEXT: Although, incidence of complete edentulism has decreased, partial edentulism is still prevalent in the country. This study aims to establish a relationship between socio-demographic variables, etiological factors, and partial edentulism. It also evaluates the prevalence of different classes of partial edentulism according to Kennedy's classification. MATERIALS AND METHODS: An institution-based, cross-sectional study was conducted on a randomly selected population in the state of Goa, India. The study group included patients who attended the Outpatient Department (OPD) of Prosthodontics during September to October, 2009. Data were acquired based on a pre-formed pro-forma (inclusive of a structured questionnaire and clinical examination) and was statistically analysed using the chi-square test. RESULTS: A total of 423 participants were enrolled for this study. Three hundred and twenty-two individuals were partially edentulous indicating a prevalence rate of 76.12%. 54.97% were females. The peak was recorded in the age group of 24-34 years, 51.24% were un-employed, 54.97% belonged to the medium income group, 58.07% resided in urban areas, 48.45% belonged to the basic educational group and 54.35% had a fair oral hygiene status. Kennedy's class III group (50.30%) was the most frequent type of partial edentulism. An association between the aforementioned characteristics and partial edentulism was recorded with a statistically significant association between partial edentulism and two characteristics, namely monthly family income and education. CONCLUSION: Partial edentulism is dependent on a combination of socio-demographic factors and the present study reveals a high prevalence rate of partial edentulism in the studied population.

Types of implant surgical guides in dentistry: a review.

Various techniques have been proposed for the fabrication of surgical guide templates in implant dentistry. The objective of this paper is to review the associated literature and recent advancements in this field, based on design concept. An electronic and hand search of the literature revealed 3 categories, namely, nonlimiting, partially limiting, and completely limiting design. Most clinicians still adopt the partially limiting design due to its cost-effectiveness and credibility. Moreover, clinicians use cross-sectional imaging during the preimplant assessment of surgical sites.