ABSTRACT
The influence on mood of anaesthesia by infusion with propofol or methohexitone was evaluated in 80 female patients assessed with the Profile of Mood State preoperatively and at 30 min, 1, 2 and 4 h after anaesthesia. Patients given propofol were more elated and continuously less anxious than those given methohexitone from 1 to 4 h after anaesthesia (54.3, SEM 1.1 vs. 50.7 SEM 1.2). They also felt more agreeable after 2 h (45.4 SEM 1.4 vs. 48.4 SEM 1.2). All patients felt more tired and more confused post-operatively than pre-operatively. Propofol has different and more favourable influences on the post-operative mood state than does methohexitone.
Subject(s)
Affect/drug effects , Anesthesia, Intravenous , Methohexital/pharmacology , Propofol/pharmacology , Adult , Ambulatory Surgical Procedures , Anxiety/psychology , Attitude , Cognition/drug effects , Confusion/physiopathology , Depression/psychology , Emotions/drug effects , Fatigue/physiopathology , Female , Hostility , Humans , Personality Inventory , Prospective StudiesABSTRACT
Psychobiological theories of mood disorders have been concerned mainly with noradrenaline and serotonin. There exists, however, a recent upsurge of interest in dopamine. We have used single photon emission computed tomography and 123I-iodobenzamide, a high-affinity ligand for D2 receptors, to study these receptors in depression. Subjects were 21 (unipolar) depressed inpatients and 11 normal controls. The mean basal ganglia/cerebellum uptake ratio was 1.94 (+/- 0.27) in the depressed patients versus 1.74 (+/- 0.17) in the controls. This difference was statistically significant (Mann-Whitney U test, p = 0.025). These data could indicate an increase of D2 receptor density in depression.
Subject(s)
Brain/diagnostic imaging , Depressive Disorder/diagnostic imaging , Dopamine/physiology , Receptors, Dopamine D2/metabolism , Tomography, Emission-Computed, Single-Photon , Adult , Basal Ganglia/diagnostic imaging , Basal Ganglia/physiopathology , Benzamides , Brain/physiopathology , Cerebellum/diagnostic imaging , Cerebellum/physiopathology , Contrast Media , Depressive Disorder/metabolism , Depressive Disorder/physiopathology , Dopamine/metabolism , Female , Humans , Male , Middle Aged , Pyrrolidines , Receptors, Dopamine D2/physiology , Up-RegulationABSTRACT
The influence of propofol on mood was evaluated, considering the potential use of propofol as an anesthetic for electroconvulsive therapy. The mood state of 80 psychologically healthy subjects was assessed before and from 1/2 hour till 4 hours after surgery under anesthesia with either propofol or methohexitone. The mood was assessed with the Profile of Mood States (POMS). The propofol group was more elated from one hour until 4 hours after anesthesia (p<0,01 )(factor 1). 1 hour after anesthesia the propofol group was continuously more composed than the methohexitone group (p<0,01) (factor 4) and after two hours the propofol group was more agreeable (p<0,05) (factor 2). Moreover, patients, who received propofol, were less tired (factor 3) and confused (factor 5). It can be concluded that, compared with methohexitone, propofol has a favorable influence on different aspects of mood.
