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1.
Med Tr Prom Ekol ; (4): 19-24, 2010.
Article in Russian | MEDLINE | ID: mdl-20560493

ABSTRACT

Toxicologic characteristics of anti-tumor medication lisomustine. The authors presented materials on experimental studies of toxicity and jeopardy to justify hygienic regulation of workplace air for antitumor medication lisomustine: data on acute toxicity, results of irritative, resorptive and sensitizing effects evaluation, mutagenous and cumulative effects, influence on reproduction.


Subject(s)
Antineoplastic Agents/toxicity , Drug Industry , Nitrosourea Compounds/toxicity , Occupational Health , Workplace , Air , Animal Experimentation , Animals , Antineoplastic Agents/administration & dosage , Data Interpretation, Statistical , Female , Lethal Dose 50 , Male , Mice , Mutagenicity Tests , Nitrosourea Compounds/administration & dosage , Rats , Reproduction/drug effects , Statistics, Nonparametric , Time Factors
2.
Med Tr Prom Ekol ; (4): 6-10, 2009.
Article in Russian | MEDLINE | ID: mdl-19514162

ABSTRACT

The article contains to forecast risk of toxic effects caused by contemporary household chemicals. The article contains data on evaluating potential risk of health disorders among individuals contacting synthetic detergents and cleansers. The authors summarized experience of Public Health Research center on toxicologic hygienic research of various household chemicals, conducted for safety certification of the end products household application.


Subject(s)
Consumer Product Safety/standards , Dermatitis, Contact/epidemiology , Household Products/adverse effects , Respiratory Tract Diseases/epidemiology , Risk Assessment/methods , Dermatitis, Contact/etiology , Dermatitis, Contact/prevention & control , Humans , Incidence , Prognosis , Respiratory Tract Diseases/chemically induced , Respiratory Tract Diseases/prevention & control , Russia/epidemiology , Safety Management
3.
Med Tr Prom Ekol ; (4): 44-7, 2009.
Article in Russian | MEDLINE | ID: mdl-19514171

ABSTRACT

The authors present materials on experimental basis of approximate safe level of exposure to new anti-flu medication Triazavirin in air of workplace. The article covers acute toxicity parameters for various intake routes, results of irritating and sensitizing effects evaluation, determination of threshold concentration for single inhalation effect, value of recommended approximate safe level of exposure.


Subject(s)
Air Pollutants, Occupational/toxicity , Azoles/toxicity , Occupational Diseases/chemically induced , Triazines/toxicity , Animals , Disease Models, Animal , Maximum Tolerated Dose , Mice , Occupational Diseases/diagnosis , Prognosis , Rats , Risk Factors , Triazoles
4.
Med Tr Prom Ekol ; (12): 5-10, 2004.
Article in Russian | MEDLINE | ID: mdl-15773376

ABSTRACT

The article covers main directions of contemporary scientific and practical activities of Industrial Toxicologic Laboratory, that were formulated by the laboratory founder--Honorary Researcher of Russian Federation, Master of Science, Professor N.V. Lazarev--and are followed by his disciples.


Subject(s)
Community Health Services/history , Hygiene/history , Laboratories/history , Toxicology/history , Community Health Services/trends , History, 20th Century , Humans , Laboratories/trends , Research/history , Research/trends , Russia , Toxicology/trends
5.
Med Tr Prom Ekol ; (11): 8-12, 1999.
Article in Russian | MEDLINE | ID: mdl-10605282

ABSTRACT

The authors present materials on hygienic regulation of such synthetic detergents as "Losk", "Dixan" in air of workplace and populated area, demonstrate results concerning evaluation of "Losk" effects. Discussion covers ways to evaluate chemical load caused by simultaneous emission of synthetic detergents from various environmental objects. For testing reliability of hygienic regulation for complex emission exemplified by "Losk", the authors suggest a model for express evaluation of complex exposure to chemicals.


Subject(s)
Detergents/adverse effects , Occupational Diseases/prevention & control , Occupational Health Services/standards , Air Pollutants/adverse effects , Animals , Chemical Industry , Female , Humans , Pregnancy , Russia
6.
Med Tr Prom Ekol ; (11): 9-12, 1998.
Article in Russian | MEDLINE | ID: mdl-9885495

ABSTRACT

Experiments on animals were conducted to study influence of following household chemical components included into synthetic washing and cleaning mixtures: anion-active surface active substances, protease Blap 200 G, Savinase 4.OT, Purafect 200 G, alkaline proteinase made in Russia, an aromatic "Magic blue". Surface active substances included into synthetic washing and cleaning mixtures were proved to increase biologic activity of chemical components of the mixtures. Powdered anion-active surface active substances, unlike liquid and paste-like ones, require hygienic regulation in air. All new components of synthetic washing and cleaning mixtures should undergo toxicologic and hygienic examination, and require studies on hygienic regulation, if found in concentrations hazardous for health.


Subject(s)
Household Products/toxicity , Air Pollutants/toxicity , Alkanesulfonic Acids/toxicity , Animals , Benzenesulfonates/toxicity , Dose-Response Relationship, Drug , Endopeptidases/toxicity , Lethal Dose 50 , Maximum Allowable Concentration , Perfume/toxicity , Quaternary Ammonium Compounds/toxicity , Rats , Skin/drug effects , Surface-Active Agents/toxicity
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