[The use of the geographic scale in health: the scales of visceral leishmaniasis]. / O uso da escala geográfica na saúde pública: as escalas da leishmaniose visceral.

The geographical scale has been broadly discussed in an attempt to formulate a concept that succeeds in explaining different space-related realities. In the various sectors of health planning, geographic categories and concepts have been adopted without understanding the problems inherent to the geographical scale, which directly affects public policies implemented and, consequently, people's lives. The scope of this paper was to discuss the concept of scale based on the different scale levels and the difficulty of their implementation by means of the activities of the organs that operate in public health surveillance that deal with visceral leishmaniasis. A systematic review of the literature was conducted to show how the debate about geographical scale and health is still incipient. Geographical concepts were used, integrating municipal, state and national policies from the perspective of the geographic scale. Thus, the contention is that cooperation between health agencies and society is possible by the transposition of scales, creating an environment of solidarity and a more effective health system. The discussion does not end here, but it will make it viable to reflect on the theoretical and methodological options in research and in public health.

A escala geográfica tem sido amplamente discutida na tentativa de formar um conceito que dê conta de explicar as diferentes realidades do espaço. Nos diversos seguimentos de planejamento em saúde, faz-se uma adoção das categorias e conceitos geográficos sem entender os problemas inerentes à escala geográfica, o que afeta diretamente nas políticas públicas implantadas e, consequentemente, na vida das pessoas. O objetivo deste artigo foi discutir o conceito de escala a partir dos seus diferentes níveis, e debater a dificuldade de articulá-los por meio da atuação dos órgãos de vigilância em saúde pública brasileira que lidam com a leishmaniose visceral. Realizamos uma revisão de literatura para demonstrar como o debate do conceito de escala geográfica com a saúde é ainda incipiente. Utilizamos conceitos geográficos, integrando as políticas municipais, estaduais e nacional sob a ótica da escala geográfica. Dessa forma, acreditamos que seja possível uma articulação dos órgãos dos sistemas de saúde com a sociedade na transposição de escalas, num acontecer solidário, produzindo um sistema de saúde mais eficaz. A discussão não será aqui esgotada, mas permitirá uma reflexão nas opções teórico-metodológicas em pesquisas e em saúde pública.

O uso da escala geográfica na saúde pública: as escalas da leishmaniose visceral / The use of the geographic scale in health: the scales of visceral leishmaniasis

Resumo A escala geográfica tem sido amplamente discutida na tentativa de formar um conceito que dê conta de explicar as diferentes realidades do espaço. Nos diversos seguimentos de planejamento em saúde, faz-se uma adoção das categorias e conceitos geográficos sem entender os problemas inerentes à escala geográfica, o que afeta diretamente nas políticas públicas implantadas e, consequentemente, na vida das pessoas. O objetivo deste artigo foi discutir o conceito de escala a partir dos seus diferentes níveis, e debater a dificuldade de articulá-los por meio da atuação dos órgãos de vigilância em saúde pública brasileira que lidam com a leishmaniose visceral. Realizamos uma revisão de literatura para demonstrar como o debate do conceito de escala geográfica com a saúde é ainda incipiente. Utilizamos conceitos geográficos, integrando as políticas municipais, estaduais e nacional sob a ótica da escala geográfica. Dessa forma, acreditamos que seja possível uma articulação dos órgãos dos sistemas de saúde com a sociedade na transposição de escalas, num acontecer solidário, produzindo um sistema de saúde mais eficaz. A discussão não será aqui esgotada, mas permitirá uma reflexão nas opções teórico-metodológicas em pesquisas e em saúde pública.

Abstract The geographical scale has been broadly discussed in an attempt to formulate a concept that succeeds in explaining different space-related realities. In the various sectors of health planning, geographic categories and concepts have been adopted without understanding the problems inherent to the geographical scale, which directly affects public policies implemented and, consequently, people's lives. The scope of this paper was to discuss the concept of scale based on the different scale levels and the difficulty of their implementation by means of the activities of the organs that operate in public health surveillance that deal with visceral leishmaniasis. A systematic review of the literature was conducted to show how the debate about geographical scale and health is still incipient. Geographical concepts were used, integrating municipal, state and national policies from the perspective of the geographic scale. Thus, the contention is that cooperation between health agencies and society is possible by the transposition of scales, creating an environment of solidarity and a more effective health system. The discussion does not end here, but it will make it viable to reflect on the theoretical and methodological options in research and in public health.

Clinical characteristics and spatial distribution of Visceral leishmaniasis in children in São Paulo state: an emerging focus of Visceral leishmaniasis in Brazil.

BACKGROUND: Visceral leishmaniasis (VL) is an emerging zoonosis, and Brazil harbors about 90% of those infected in Latin America. Since 1998, the disease has been spreading quickly in São Paulo state, and the western region is considered an emerging focus of VL in Brazil. Our aim was to evaluate the clinical characteristics and spatial distribution of VL in children referred to a public tertiary hospital located in the western region of São Paulo state, Brazil. METHODS: Medical records of children up to 18 years of age who were diagnosed with VL between January 2006 and December 2010 were reviewed. Geospatial analysis was performed using the ArcGIS 10.2 platform. RESULTS: Sixty-three patients were enrolled in the study; the median age was 3.3 ± 3.3 years. The median time interval between the onset of clinical symptoms and diagnosis was 16.1 ± 11.1 days, and the median time in the pediatric ward was 18.0 ± 9.4 days. Liposomal amphotericin B was the first-line treatment in 90.5% of the patients and 9.6% relapsed. One patient died (1.6%), and 19% were submitted to the pediatric intensive care unit. CONCLUSION: The short interval between the onset of symptoms, diagnosis, and treatment and the reduced number of days of hospitalization certainly influenced the small number of deaths, relapses, and severity among the children infected with VL. However, the disease is spreading fast in the western region of São Paulo state. Thus, integrated actions and effective monitoring of the disease are needed to complement curative practices.

The shadows of a ghost: a survey of canine leishmaniasis in Presidente Prudente and its spatial dispersion in the western region of São Paulo state, an emerging focus of visceral leishmaniasis in Brazil.

BACKGROUND: Visceral leishmaniasis is an emerging zoonosis and its geographic distribution is restricted to tropical and temperate regions. Most of the individuals infected in Latin America are in Brazil. Despite the control measures that have been adopted, the disease is spreading throughout new regions of the country. Domestic dogs are involved in the transmission cycle and are considered to be the main epidemiologic reservoir of Leishmania infantum (syn. L. chagasi). Our aim was to determine the prevalence of canine leishmaniasis (CL) and Ehrlichiosis infection in Presidente Prudente as well as the spatial dispersion of the disease in the western region of São Paulo state. METHODS: Dogs underwent clinical examination and symptoms related to CL were recorded. Anti- Leishmania antibodies were detected using ELISA, rK39-immunocromatographic tests (DPP), and an indirect fluorescent antibody test (IFAT). Anti-E. canis antibodies were detected by IFAT. A follow-up was conducted in dogs that were positive in the ELISA at the baseline study. Data on the spatial distribution of L. longipalpis and CL in São Paulo state were obtained from Brazilian public health agencies. RESULTS: Serum samples from 4547 dogs were analyzed. The seroprevalence of CL was 11.2% by ELISA and 4.5 % by IFAT. In the follow-up, seroprevalence was 32.9% by ELISA, 15.3% by IFAT, 11.8 % by DPP test, and 66.5% for E. canis. There was a significant positive association between Leishmania and E. canis infection (P < 0.0001). In the follow-up, clinical examinations revealed symptoms compatible with CL in 33.5% of the dogs. L. longipalpis was found in 24 and CL in 15 counties of the Presidente Prudente mesoregion. The dispersion route followed the west frontier of São Paulo state toward Paraná state. CONCLUSIONS: Low CL and high ehrlichiosis prevalence rates were found in Presidente Prudente city. This emerging focus of CL is moving through the western region of São Paulo state toward the border of Paraná state. Integrated actions to fight the vector, parasites, infected dogs, and humans are needed to monitor the disease and implement strategies for epidemiologic control.

Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil.

Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to the University Regional Hospital of the West Region of state of São Paulo, Brazil. Among a total of 7,021 individuals seen in the clinic following receipt of preliminary ELISA results or having the suggested clinical signs of viral hepatitis or HIV, 1,228 were systematically screened. Isolated or associated HBsAg, HCV and HIV antibodies were found in 44.9% of the subjects. Anti-HIV antibodies were found in 24.7% of the patients, 20.3% of whom had an HIV monoinfection and 4.4% of whom were co-infected with hepatitis viruses (HCV: 4%; HBV: 0.4%). Anti-HCV antibodies were found in 14% of the patients and 5.9% had anti-HBsAg antibodies. HCV infection affected males more than females (p < 0.05) and individuals > 50-years old had an increased prevalence of anti-HCV compared to HIV (p = 0.0001) or HBV (p = 0.0063). HCV-RNA was detected in 73.5% of the samples with a predominance of genotype 1 (72.5%). A significant percentage (44.9%) of the selected individuals was positive for antibodies against HBV, HCV and/or HIV; these patients would otherwise have remained undiagnosed.

Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil

Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to the University Regional Hospital of the West Region of state of São Paulo, Brazil. Among a total of 7,021 individuals seen in the clinic following receipt of preliminary ELISA results or having the suggested clinical signs of viral hepatitis or HIV, 1,228 were systematically screened. Isolated or associated HBsAg, HCV and HIV antibodies were found in 44.9 percent of the subjects. Anti-HIV antibodies were found in 24.7 percent of the patients, 20.3 percent of whom had an HIV monoinfection and 4.4 percent of whom were co-infected with hepatitis viruses (HCV: 4 percent; HBV: 0.4 percent). Anti-HCV antibodies were found in 14 percent of the patients and 5.9 percent had anti-HBsAg antibodies. HCV infection affected males more than females (p < 0.05) and individuals > 50-years old had an increased prevalence of anti-HCV compared to HIV (p = 0.0001) or HBV (p = 0.0063). HCV-RNA was detected in 73.5 percent of the samples with a predominance of genotype 1 (72.5 percent). A significant percentage (44.9 percent) of the selected individuals was positive for antibodies against HBV, HCV and/or HIV; these patients would otherwise have remained undiagnosed.