1.
Cesk Pediatr
; 45(6): 362-6, 1990 Jun.
Article
in Slovak
| MEDLINE
| ID: mdl-2289258
2.
Strahlenther Onkol
; 162(3): 200-4, 1986 Mar.
Article
in English
| MEDLINE
| ID: mdl-3961677
ABSTRACT
The radioprotective effect of the Bulgarian drug Adeturone was tested on prolonged irradiated monkeys. The animals were gamma-irradiated (137Cs) in a dose of 8.3 Gy (exposure rate 3.95 X 10(-3) mA.kg-1; (0.92 R.min-1]. Adeturone, given by i.v. injection at a dose of 100 mg.kg-1 body weight according to a pre- and postradiation scheme will afford protection to monkeys by ensuring 50% survival and mitigating the severity of some symptoms of radiation disease. A similar effect was obtained with ATP-administration by two i.m. injections of 37 mg.kg-1 body weight. The survival in control group was only 5% (LD95/45).
Subject(s)
Adenosine Triphosphate/analogs & derivatives , Radiation Injuries, Experimental/prevention & control , Radiation-Protective Agents/therapeutic use , beta-Aminoethyl Isothiourea/analogs & derivatives , Adenosine Triphosphate/therapeutic use , Animals , Drug Evaluation, Preclinical , Female , Gamma Rays , Macaca mulatta , Male , Radiation Injuries, Experimental/mortality , Radiation Injuries, Experimental/pathology , Time Factors , beta-Aminoethyl Isothiourea/therapeutic use
3.
Neoplasma
; 19(4): 335-40, 1972.
Article
in English
| MEDLINE
| ID: mdl-4341020
Subject(s)
Neoplasms/enzymology , Adenine/metabolism , Animals , Carbon Isotopes , Carcinoma, Hepatocellular/enzymology , Carcinoma, Hepatocellular/metabolism , Catalase/metabolism , Cholesterol/biosynthesis , DNA, Neoplasm/biosynthesis , Humans , Isoenzymes , L-Lactate Dehydrogenase/metabolism , Leukemia, Lymphoid/enzymology , Leukemia, Myeloid/enzymology , Leukocytes/enzymology , Liver/enzymology , Liver/metabolism , Liver Neoplasms/metabolism , Lymphocytes/enzymology , Neoplasms, Experimental/enzymology , Orotic Acid/metabolism , Pyrimidine Nucleotides/biosynthesis , RNA, Neoplasm/biosynthesis , Rats , Uracil/metabolism
4.
Prog Nucleic Acid Res Mol Biol
; 11: 81-101, 1971.
Article
in English
| MEDLINE
| ID: mdl-4326861
Subject(s)
Endoplasmic Reticulum , Lipoproteins , Membranes , RNA , Animals , Carcinoma/pathology , Carcinoma, Hepatocellular/pathology , Cell Fractionation , Cell Membrane/analysis , Cell Nucleus/analysis , Centrifugation, Density Gradient , Endoplasmic Reticulum/analysis , Female , Lipoproteins/isolation & purification , Liver/cytology , Liver Neoplasms , Membranes/analysis , Mice , Microsomes, Liver/analysis , Mitochondria/analysis , Models, Biological , Molecular Weight , Nucleoproteins , Ovarian Neoplasms/pathology , Protein Binding , Purines/analysis , Pyrimidines/analysis , RNA/analysis , RNA/isolation & purification , Rats , Spectrophotometry , Ultraviolet Rays
5.
Biochim Biophys Acta
; 220(2): 206-12, 1970 Nov 11.
Article
in English
| MEDLINE
| ID: mdl-4321166
Subject(s)
Carcinoma, Hepatocellular/enzymology , Catalase , Liver/enzymology , Alcohols , Animals , Bile Acids and Salts , Carcinoma, Hepatocellular/immunology , Cell Membrane/enzymology , Female , Flufenamic Acid/immunology , Lipids , Liver/cytology , Liver/embryology , Liver Neoplasms , Liver Regeneration , Mice , Microsomes, Liver/enzymology , Mitochondria, Liver/enzymology , Neoplasm Transplantation , Neoplasms, Experimental , Phosphates , Pregnancy , Rats , Solubility
6.
7.
Biochim Biophys Acta
; 158(2): 303-5, 1968 May.
Article
in English
| MEDLINE
| ID: mdl-4297594
