ABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Breast Neoplasms/therapy , Carcinoma, Basal Cell/diagnosis , Neoplasms, Second Primary/diagnosis , Skin Neoplasms/diagnosis , Anilides/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Neoplasms, Second Primary/drug therapy , Pyridines/therapeutic use , Skin Neoplasms/drug therapy , Thoracic WallSubject(s)
Breast Neoplasms/therapy , Carcinoma, Basal Cell/diagnosis , Neoplasms, Second Primary/diagnosis , Skin Neoplasms/diagnosis , Aged , Anilides/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Basal Cell/drug therapy , Female , Humans , Neoplasms, Second Primary/drug therapy , Pyridines/therapeutic use , Skin Neoplasms/drug therapy , Thoracic WallABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Breast/pathology , Breast Diseases/etiology , Breast Diseases/pathology , Lymphoma, T-Cell/complications , Biopsy , Necrosis/etiology , Positron-Emission TomographyABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Acrospiroma/diagnosis , Acrospiroma/surgery , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Sweat Gland Diseases/diagnosis , Sweat Gland Diseases/surgery , Immunohistochemistry , Early DiagnosisABSTRACT
A role of GLP-1 (glucagon-like peptide-1) in the recovery of the metabolic conditions of morbidly obese patients after bariatric surgery has been proposed. Exendin 4 (Ex-4) and exendin 9 (Ex-9) both have GLP-1-like effects upon glucose metabolism in human myocytes. We investigated in normal human adipocytes the effect of GLP-1, Ex-4 and Ex-9, compared with insulin upon the activity of PI3K, PKB, MAPKs and p70s6 kinases, and the participation of these enzymes in their action upon 2-deoxy-D-glucose transport by using potential inhibitors. The study was extended to morbidly obese patients. In normal subjects, GLP-1, Ex-4 and insulin, but not Ex-9, increased glucose uptake. In addition, GLP-1 and Ex-4 stimulated PI3K and MAPKs, similar to insulin, but not PKB. Ex-9 only enhanced PI3K, while none affected p70s6k. Inhibition of both PI3K and MAPKs blocked the stimulatory action of GLP-1, Ex-4 and insulin upon glucose transport. In obese patients, basal PI3K, PKB and MAPK activity was, as a rule, lower than that in normal subjects, while cells maintained their normal incremental response to GLP-1, Ex-4 or insulin; Ex-9 induced a clear stimulation of p42 MAPK. In summary, in normal human adipocytes, GLP-1 and Ex-4 have a protein kinase-dependent increasing effect upon glucose transport, which is impaired in obese patients. The participation of GLP-1 in the normalization of the metabolic conditions of the obese may occur through its effects on lipid metabolism or through effects upon glucose transport and/or metabolism in the liver and muscle, which in human obesity remain to be investigated.
