ABSTRACT
The biological characteristics of 11 HIV-1 strains isolated from patients with a fast clinical evolution to AIDS were studied. The viral isolates were classified according to their replication kinetics and cell tropism. Taking into account these criteria, it was observed that 8 of the isolated strains (72.7%) were of rapid high growth (RH) or slow low 3 (SL3) with preferential tropism to the lymphocytic stock, as it corresponds to AIDS patients. 3 (27.3%) had characteristics of slow low 1 (SL1). The cytopathogenicity of the strains was studied in the MT4 cellular line, and it was observed that most of them (72.7%) were syncytium-inducing strains (SI), which allowed to prove the in vivo and in vitro relation of the biological properties. It was not so in 3 of the cultures (27.3%) that behaved as non-syncytium inducers.
