ABSTRACT
BACKGROUND/AIMS: Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. METHODS: We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients was compared with that found in untreated chronic hepatitis C patients. All patients were white and most were Spaniards. RESULTS: In multivariate analysis ALT values were higher (P = 0.001) and GGT values were lower (P<0.001) in chronic hepatitis C patients homozygotes for the major rs12979860C allele as compared with carriers of the mutated rs12979860T allele. Steatosis was more frequent (Odds ratio = 1.764, 95% C.I. 1.053-2.955) and severe (P = 0.026) in carriers of the rs12979860T allele. No relation was found between the analysed SNP and METAVIR scores for necroinflammation and fibrosis, and there were no differences in the distribution of the analysed SNP between hepatocellular carcinoma and untreated chronic hepatitis C patients. CONCLUSION: The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.
Subject(s)
Hepacivirus/pathogenicity , Interleukins/genetics , Liver Diseases/genetics , Liver Diseases/pathology , Polymorphism, Single Nucleotide , Carcinoma, Hepatocellular/genetics , Carcinoma, Hepatocellular/pathology , Carcinoma, Hepatocellular/virology , Female , Hepatitis C, Chronic/genetics , Hepatitis C, Chronic/pathology , Hepatitis C, Chronic/virology , Humans , Interferons , Liver Diseases/virology , Liver Neoplasms/genetics , Liver Neoplasms/pathology , Liver Neoplasms/virology , Male , Middle Aged , PhenotypeABSTRACT
El lipoleiomiosarcoma corresponde a un liposarcoma bien diferenciado que muestra focalmente diferenciación hacia tejido muscular liso maduro con atipia. La localización característica es el retroperitoneo, aunque se han descrito casos en otras localizaciones, siendo raros en la región inguinal-paratesticular. El comportamiento de las lesiones es similar al liposarcoma bien diferenciado, siendo clave en el pronóstico de la lesión la localización y, en relación a esta, la posibilidad o no de extirpación quirúrgica completa. Presentamos dos casos de localización paratesticular y revisamos la literatura(AU)
Lipoleiomyosarcoma is a well differentiated liposarcoma with focal differentiation into mature smooth muscle with atypia. These tumours usually occur in the retroperitonum, although they have been reported in other locations. The inguinal paratesticular region is a rare site for these neoplasms. Their behaviour is similar to that of well differentiated liposarcomas. Their location and the possibility of complete surgical extirpation are key prognostic factors. Two cases of lipoleiomyosarcoma occurring in the paratesticular region are presented together with a review of the literature(AU)
