1.
Ann N Y Acad Sci
; 521: 123-8, 1988.
Article
in English
| MEDLINE
| ID: mdl-3288038
Subject(s)
Endorphins/pharmacology , Hematopoiesis/drug effects , Animals , Bone Marrow Transplantation , Cell Differentiation/drug effects , Colony-Forming Units Assay , Colony-Stimulating Factors/pharmacology , Gene Expression Regulation/drug effects , Humans , Leukemia, Myeloid, Acute/pathology , Mice , Mice, Inbred CBA , Tumor Cells, Cultured/drug effects
2.
Biochem Biophys Res Commun
; 146(3): 976-82, 1987 Aug 14.
Article
in English
| MEDLINE
| ID: mdl-3619945
ABSTRACT
All trans retinoic acid inhibited diferric transferrin reduction by HeLa cells. The NADH diferric transferrin reductase activity of isolated liver plasma membranes was also inhibited by retinoic acid. Retinol and retinyl acetate had very little effect. Transplasma membrane ferricyanide reduction by HeLa cells and NADH ferricyanide reductase of liver plasma membrane was also inhibited by retinoic acid, therefore the inhibition was in the electron transport system and not at the transferrin receptor. Since the transmembrane electron transport has been shown to stimulate cell growth, the growth inhibition by retinoic acid thus may be based on inhibition of the NADH diferric transferrin reductase.