ABSTRACT
Endophenotypes have emerged as an important concept in the study of schizophrenia. Perceptual/attentional anomalies were examined as potential endophenotypes in a family study using a strategy for "multiplex/simplex schizophrenia". The sample was comprised of 797 subjects: 206 schizophrenia patients, 302 first-degree relatives and 289 controls. The Spanish versions of the Structured Interview for Assessing Perceptual/attentional Anomalies (SIAPA) and Positive and Negative Symptoms Scale (PANSS) were applied to measure the presence of perceptual/attentional anomalies, and positive and negative subscale respectively. An ANCOVA was carried out for global comparisons between groups. The multiplex schizophrenic group had significantly more frequent auditory and visual perceptual/attentional anomalies than Simplex schizophrenic and control groups. The most interesting finding was that the severity of auditory and visual perceptual/attentional anomalies and negative symptoms was significantly higher in the relatives of the multiplex schizophrenia group than in those relatives from the simplex schizophrenia and control groups. The existence of perceptual/attentional anomalies in nonaffected relatives suggests the presence of familial association for these symptoms which may therefore be a potential endophenotype suitable for genetic studies.
