ABSTRACT
Orally ingested probiotic bacteria are able to modulate the immune system. However, differences exist in the immunomodulatory effects of different probiotic strains. Moreover, different regulatory effects, which depend on the health status of the consumer, have been identified. This work describes a randomized, double-blind, placebo-controlled human clinical trial to investigate the immune effects on healthy people of a fermented product containing two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, which was compared with another fermented product, a standard yogurt. Consumption of either the new product or yogurt increased the proportion of phagocytic cells, including monocytes and neutrophils, as well as their phagocytic activity. However, combination of the product containing the strains L. gasseri CECT 5714 and L. coryniformis CECT 5711 also induced an increase in the proportion of natural killer (NK) cells and in IgA concentrations. The effects were higher after two weeks of treatment than after 4 weeks, which suggests regulation of the immune system. In addition, the new product enhanced immunity in the participants to a greater extent than did the control standard yogurt.
Subject(s)
Antibody Formation , Immunity, Cellular , Lactobacillus , Probiotics/administration & dosage , Adult , Cytokines/immunology , Female , Humans , Immunoglobulins/immunology , Male , Phagocytosis/immunology , T-Lymphocyte Subsets/immunology , Yogurt/microbiologyABSTRACT
Orally ingested probiotic bacteria are able to modulate the immune system. However, differences exist in the immunomodulatory effects of different probiotic strains. Moreover, different regulatory effects, which depend on the health status of the consumer, have been identified. This work describes a randomized, double-blind, placebo-controlled human clinical trial to investigate the immune effects on healthy people of a fermented product containing two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, which was compared with another fermented product, a standard yogurt. Consumption of either the new product or yogurt increased the proportion of phagocytic cells, including monocytes and neutrophils, as well as their phagocytic activity. However, combination of the product containing the strains L. gasseri CECT 5714 and L. coryniformis CECT 5711 also induced an increase in the proportion of natural killer (NK) cells and in IgA concentrations. The effects were higher after two weeks of treatment than after 4 weeks, which suggests regulation of the immune system. In addition, the new product enhanced immunity in the participants to a greater extent than did the control standard yogurt (AU)
La ingestión oral de bacterias probióticas puede modular el sistema inmunitario. Sin embargo, existen diferencias en los efectos inmunomoduladores de diferentes cepas probióticas. Además, se han identificado distintos efectos reguladores, que dependen del estado de salud del consumidor. Este trabajo describe un ensayo clínico aleatorizado, con ocultación doble (double blind) y con control de placebo llevado a cabo en humanos para estudiar los efectos inmunitarios del consumo de un producto fermentado que contiene dos nuevas cepas probióticas, Lactobacillus gasseri CECT 5714 y Lactobacillus coryniformis CECT 5711, comparados con los efectos producidos por otro producto fermentado, un yogurt clásico. El consumo del nuevo producto o del yogurt clásico aumentó la proporción de células fagocitarias, como monocitos y neutrófilos, así como su actividad fagocitaria. Sin embargo, la combinación del producto que contenía las cepas L. gasseri CECT 5714 y L. coryniformis CECT 5711 indujo además un aumento en la proporción de linfocitos citolíticos natuales (células NK) y en las concentraciones de IgA. Estos efectos fueron más acusados después de dos semanas de tratamiento que después de 4 semanas, lo que sugiere una regulación del sistema inmunitario. Además, el nuevo producto reforzó la inmunidad en las personas que participaron en el ensayo más que el yogur clásico usado como control (AU)
