ABSTRACT
BACKGROUND: Type 2 diabetes mellitus (T2DM) is the leading cause of chronic kidney disease and a major cause of cardiovascular disease (CVD) mortality. Inflammation is closely involved in the pathogenesis of T2DM, and reactive amyloidosis occurs in the presence of chronic inflammation. We hypothesized that patients with T2DM may have a higher prevalence of renal AA amyloidosis (RAAA) and that this could contribute to worse atherosclerosis and CVD. MATERIALS AND METHODS: We analyzed 330 autopsy kidneys from patients with a previous T2DM diagnosis. The kidney tissue was evaluated in order to determine the presence of diabetic nephropathy and RAAA, and systemic vessels were evaluated for the presence of atherosclerosis. RESULTS: RAAA was detected in 9% of our study population and was associated with an increased risk for nodular sclerosis [OR (95% CI)] [11 (2.04-59.16)], for chronic ischemic cardiomyopathy [4.59 (2.02-10.42)], for myocardial infarction [3.41 (1.52-7.64)] as well as for aortic [4.75 (1.09-20.69)], coronary [3.22 (1.47-7.04)], and intrarenal atherosclerosis [3.84 (1.46-10.09)]. CONCLUSIONS: RAAA is prevalent in T2DM and is associated with worse CVD and renal disease, likely because RAAA is a marker of severe chronic inflammation.
ABSTRACT
La concentracion de la poblacion migrante en edades activas y el peso significativo que tiene esta en el conjunto dela poblacion contribuye al elevado crecimiento de la PET, de tal manera que en los ultimos años la tas de crecimiento de la PET ha experimentado un incremento mayor que el de la PEA y el de la poblacion total (PT)...
Subject(s)
UnemploymentABSTRACT
El presente documento contiene informacion sobre los niveles y tendencias de la participacion laboral del apoblacion, los sectores de mercado de trabajo, rama de actividad, ocupacion, categoria ocupacional ingresos por trabajo, relacionada con algunos atributos como el sexo y el nivel de instrucción...
