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Alkyne-azide click chemistry mediated carbanucleosides synthesis.

Broggi, Julie; Joubert, Nicolas; Aucagne, Vincent; Berteina-Raboin, Sabine; Diez-Gonzalez, S; Nolan, Steve; Topalis, Dimitri; Deville-Bonne, Dominique; Balzarini, Jan; Neyts, Johan; Andrei, Graciela; Snoeck, Robert; Agrofoglio, Luigi A.

Nucleosides Nucleotides Nucleic Acids ; 26(10-12): 1391-4, 2007.

Article in English | MEDLINE | ID: mdl-18066789

ABSTRACT

Hitherto unknown 1,4-disubstituted-[1,2,3]-triazolo-4',4'-dihydroxymethyl-3'-deoxy carbanucleosides were synthesized based on a "click approach." Various alkynes were introduced on a key azido intermediate by the "click" 1,3-dipolar Huisgen cycloaddition. Their antiviral activities and cellular toxicities were evaluated on vaccinia virus. None of the synthesized compounds exhibited a significant antiviral activity.

Subject(s)

Alkynes/chemistry , Antiviral Agents/chemical synthesis , Azides/chemistry , Nucleosides/chemical synthesis , Triazoles/chemical synthesis , Cyclization , Microwaves , Molecular Structure

Análisis estacional de brotes de esclerosis múltiple y su relación con diferentes variables climatológicas / Seasonal analysis of outbreaks of multiple sclerosis and their relation to different climatologic variables

Guerrero Peral, AL; Carrasco Cavia, E; Díez González, S; Fernández, MJ; Martín Polo, JM; Bueno Rodríguez, V.

Rev. neurol. (Ed. impr.) ; 41(7): 446-448, 1 oct., 2005. graf

Article in Es | IBECS | ID: ibc-040702

ABSTRACT

No disponible

Subject(s)

Humans , Multiple Sclerosis/epidemiology , Multiple Sclerosis/physiopathology , Prevalence , Climate Effects , Meteorological Concepts , Retrospective Studies

[Seasonal analysis of outbreaks of multiple sclerosis and their relation to different climatologic variables]. / Análisis estacional de brotes de esclerosis múltiple y su relación con diferentes variables climatológicas.

Guerrero-Peral, A L; Carrasco-Cavia, E; Díez-González, S; Fernández, M J; Martín-Polo, J M; Bueno-Rodríguez, V.

Rev Neurol ; 41(7): 446-8, 2005.

Article in Spanish | MEDLINE | ID: mdl-16193453

Subject(s)

Climate , Multiple Sclerosis , Seasons , Adolescent , Child , Disease Outbreaks , Disease Susceptibility , Humans , Humidity , Multiple Sclerosis/epidemiology , Multiple Sclerosis/etiology , Multiple Sclerosis/physiopathology

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