ABSTRACT
Cyclophosphamide (CYC) is a classical drug for the treatment of severe granulomatosis with polyangiitis (GPA). However, a considerable number of patients are resistant to standard treatment and it can show substantial toxicity. Therefore, alternative agents should be considered in refractory cases. We report the successful use of rituximab (RTX) in a 70-year-old patient diagnosed of GPA who developed ophthalmoplegia, an uncommon complication of GPA. The patient also had upper and lower respiratory tract involvement and kidney manifestations with good prognosis. We review the causes of ophtalmoparesis and the treatment with RTX in GPA.
Subject(s)
Granulomatosis with Polyangiitis/drug therapy , Kidney Diseases/drug therapy , Lung Diseases/drug therapy , Ophthalmoplegia/drug therapy , Rituximab/therapeutic use , Aged , Female , Granulomatosis with Polyangiitis/complications , Humans , Kidney Diseases/etiology , Lung Diseases/etiology , Ophthalmoplegia/etiology , Remission InductionABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Infant, Newborn , Lyme Disease/diagnosis , Lyme Disease/epidemiology , Lyme Disease/therapy , Epidemiological Monitoring , Early Diagnosis , Disease Prevention , Epidemiology, Descriptive , Observational Study , Retrospective Studies , Spain/epidemiologyABSTRACT
The effect of three routinely used disinfectants on the embryonary development of Toxocara canis eggs was evaluated both in vivo and in vitro. In the in vitro experiment, T. canis eggs were treated with the ethanol, sodium hypochlorite, and one commercial mix of benzalconium chloride and formaldehyde, and the embryonary development was assessed. After a period of 24 days incubation, ethanol was the best disinfectant because it prevented the development of the T. canis larvae 2 in the eggs, and sodium hypochlorite caused degeneration in 50% eggs. By using the commercial mix, 25% T. canis eggs developed to 2nd stage larvae. In the in vivo experiment, the embryonated eggs treated with the disinfectants were inoculated to mice, and their brain tissues were examined for larval presence on the 24th day postinfection. In addition, a control group was set up for comparison with the infected groups. No injury or T. canis larvae were observed in mice infected with sodium hypochlorite-treated eggs, opposite to that recorded in the animals infected with the commercial disinfectant-treated eggs. These results showed that both ethanol and sodium hypochlorite are very appropriate because of their full efficacy against infective T. canis eggs. Disinfection of kennels, animal shelters, cages, and veterinary clinics with one of these products to eliminate T. canis eggs and to avoid contamination is strongly recommended.
