ABSTRACT
Bordetella holmesii is a rare cause of human infection, mainly in the immunocompromised host, and is associated with bacteremia, respiratory tract infection and endocarditis. Herein, we describe a patient with severe relapse of nephrotic syndrome associated with bacteremic B. holmesii pneumonia.
Subject(s)
Bordetella/classification , Community-Acquired Infections/microbiology , Nephrotic Syndrome/complications , Pneumonia, Bacterial/microbiology , Adolescent , Bordetella/genetics , Bordetella/isolation & purification , Community-Acquired Infections/diagnosis , DNA, Bacterial/analysis , DNA, Bacterial/isolation & purification , Humans , Male , Molecular Sequence Data , Pleural Effusion/microbiology , Pneumonia, Bacterial/diagnosis , RNA, Ribosomal, 16S/genetics , Recurrence , Sequence Analysis, DNAABSTRACT
OBJECTIVES: In vitro susceptibility testing of 31 Bartonella spp. strains including 21 Bartonella henselae isolates was performed for 17 antimicrobial agents (telithromycin, four macrolides, five fluoroquinolones, five aminoglycosides, doxycycline and rifampicin). METHODS: MICs were determined by agar dilution and Etest using chocolate agar containing 5% defibrinated sheep blood as assay medium. Longer incubation periods of 3-5 days in a humid atmosphere with 5% CO(2) were required until bacterial growth became visible and MICs could be read. RESULTS: The ketolide telithromycin was the most active agent exhibiting the lowest MICs. The Bartonella spp. were also highly susceptible to macrolides, particularly clarithromycin, and to doxycycline and rifampicin, with MICs of Subject(s)
Anti-Bacterial Agents/pharmacology
, Bartonella/drug effects
, Agar
, Animals
, Bartonella/classification
, Cats
, Culture Media
, Humans
, Microbial Sensitivity Tests/methods
