Proposition of In silico Pharmacophore Models for Malaria: A Review.

In the field of medicinal chemistry, the concept of pharmacophore refers to the specific region of a molecule that possesses essential structural and chemical characteristics for binding to a receptor and eliciting biological activity. Understanding the pharmacophore is crucial for drug research and development, as it allows the design of new drugs. Malaria, a widespread disease, is commonly treated with chloroquine and artemisinin, but the emergence of parasite resistance limits their effectiveness. This study aims to explore computer simulations to discover a specific pharmacophore for Malaria, providing new alternatives for its treatment. A literature review was conducted, encompassing articles proposing a pharmacophore for Malaria, gathered from the "Web of Science" database, with a focus on recent publications to ensure up-to-date analysis. The selected articles employed diverse methods, including ligand-based and structurebased approaches, integrating molecular structure and biological activity data to yield comprehensive analyses. Affinity evaluation between the proposed pharmacophore and the target receptor involved calculating free energy to quantify their interaction. Multiple linear regression was commonly utilized, though it is sensitive to multicollinearity issues. Another recurrent methodology was the use of the Schrödinger package, employing tools such as the Phase module and the OPLS force field for interaction analysis. Pharmacophore model proposition allows threedimensional representations guiding the synthesis and design of new biologically active compounds, offering a promising avenue for discovering therapeutic agents to combat Malaria.

Computed tomography angiography study of variations of the celiac trunk and hepatic artery in 100 patients.

OBJECTIVE: To describe the main anatomical variations of the celiac trunk and the hepatic artery at their origins. MATERIALS AND METHODS: This was a prospective analysis of 100 consecutive computed tomography angiography studies of the abdomen performed during a one-year period. The findings were stratified according to classification systems devised by Sureka et al. and Michels. RESULTS: The celiac trunk was "normal" (i.e., the hepatogastrosplenic trunk and superior mesenteric artery originating separately from the abdominal aorta) in 43 patients. In our sample, we identified four types of variations of the celiac trunk. Regarding the hepatic artery, a normal anatomical pattern (i.e., the proper hepatic artery being a continuation of the common hepatic artery and bifurcating into the right and left hepatic arteries) was seen in 82 patients. We observed six types of variations of the hepatic artery. CONCLUSION: We found rates of variations of the hepatic artery that are different from those reported in the literature. Our findings underscore the need for proper knowledge and awareness of these anatomical variations, which can facilitate their recognition and inform decisions regarding the planning of surgical procedures, in order to avoid iatrogenic intraoperative injuries, which could lead to complications.

Integralidade e suas interfaces com a produção do cuidado / Integralidad y sus interfaces con la producción de cuidado / Completeness and interfaces with the production of care

Introdução: Trata-se de uma revisão integrativa que tem como objetivos analisar as concepções de integralidade e de cuidado de saúde (e de enfermagem) evidenciada nos artigos encontrados na Biblioteca Virtual em Saúde e conhecer a relação entre integralidade e o cuidado em saúde na Atenção Primária à Saúde, relatados entre os trabalhos encontrados na BVS. Materiais e Métodos: Foi feita a seleção dos artigos que tinham como principal assunto a Atenção Primária à Saúde, publicados e indexados no banco de dados National Library of Medicine e Literatura Latino-Americana e do Caribe em Ciências da Saúde. Totalizaram 09 artigos publicados no período de 2010 a 2012. A análise dos materiais se deu através da análise de conteúdo de Bardin. Resultados e Discussão: Mostrou-se a necessidade de que a enfermagem reconheça a integralidade como norteadora de suas práticas de saúde, valendo-se do trabalho vivo em saúde para a produção do cuidado. Ao mesmo tempo em que identifiquem em seu cotidiano as várias formas de efetuá-lo, garantindo assistência de qualidade, cuidado, corresponsabilização, vínculo e intersetorialidade, na medida em que se busca a longitudinalidade do cuidado em saúde. Conclusões: A partir dos estudos reconhece-se que a integralidade é vista como um ponto chave para a produção do cuidado, desde que sejam contempladas as necessidades reais dos indivíduos, em atividades cotidianas da Atenção Primária à Saúde, no que engloba a mudança de concepções entre o modelo biomédico, ainda predominante, para um olhar que tenha foco as várias dimensões dos indivíduos.

Introducción: Se trata de una revisión integrativa que tiene como objetivos analizar las concepciones de integralidad y de cuidado de salud (y de enfermería) evidenciada en los artículos encontrados en la Biblioteca Virtual en Salud (BVS) y conocer la relación entre la integralidad y el cuidado de salud en atención primaria a la salud, reportados en los trabajos hallados en la BVS. Materiales y Métodos: Se realizó la selección de artículos que tenían como principal tema la atención primaria en salud, publicados e indexados en la base de datos de la Biblioteca Nacional de Medicina y de la Literatura Latinoamericana y del Caribe en Ciencias de la Salud. Fueron en total 09 artículos publicados en el período 2010-2012. El Análisis de los materiales se realizó a través del análisis de contenido de Bardin. Resultados y Discusión: Se mostró la necesidad de que la enfermería reconozca a la integralidad como guía a sus prácticas de salud, aprovechando el trabajo vivo en salud para la producción del cuidado. Asimismo, que identifiquen en su cotidiano las diversas formas de realizar el trabajo, garantizando una atención de calidad, cuidado, corresponsabilidad, vínculo e intersectorialidad, en la medida en que se busca el cuidado longitudinal en salud. Conclusiones: A partir de los estudios se reconoce que la integralidad es vista como un punto clave para la producción del cuidado, siempre que se aborden las necesidades reales de las personas, en actividades cotidianas de Atención Primaria en Salud, que abarquen los cambios de concepciones entre el modelo biomédico, todavía predominante, para una mirada que tenga foco a varias dimensiones de los individuos.

Introduction: It is integrative review aims to examine the concepts of wholeness and health care (and nursing) evidenced in articles found on the Virtual Health Library (VHL) and know the relationship between completeness and health care in Primary Care Health, reported from studies in the VHL. Materials and Methods: A selection of articles whose principal subject for Primary Health Care, published and indexed in the database National Library of Medicine and the Latin American and Caribbean Literature on Health Sciences Totaled 09 published articles was made in period from 2010 to 2012. Analysis of the materials was made through the content analysis of Bardin. Results and Discussion: showed the need to recognize that nursing comprehensiveness as guiding their health practices, taking advantage of living labor in health care production. While identifying in their daily lives the various forms commencing the work, ensuring quality care, care, co-responsibility, bond and intersectionality, insofar as it seeks longitudinally of health care. Conclusions: From the studies it is recognized that comprehensiveness is seen as a key point for the production of care, provided they are addressed the real needs of individuals in everyday activities of Primary Health Care, which encompasses the changing conceptions between the still predominant biomedical model for a look that has focus the various dimensions of individuals.