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1.
Cell Mol Biol (Noisy-le-grand) ; 63(9): 13-17, 2017 Sep 30.
Article in English | MEDLINE | ID: mdl-28980916

ABSTRACT

Cetuximab is a chimeric monoclonal antibody that acts as a competitive antagonist, by binding to EGFR. This cell signalling pathways regulates tumor progression. The oral squamous cell carcinoma undergoes to regional spreading and distant metastasis. This study aimed to evaluate the effect of treatment with Cetuximab on cell migration and invasion in OSCC cells, by using the SCC-4 cell line. Cell migration and cell invasion assay were performed and actin cytoskeleton of control and treated with Cetuximab cells were evaluated. Differences were considered significant when p<0.05.Cetuximab inhibited the migration of SCC-4 cells at three concentrations: 1 µg/mL, 50 µg/mL and 100 µg/mL (p<0.0001) in a dose-dependent manner. The number of SCC-4 treated cells with 1 µg/mL that migrated through the membrane was statistically different from 50 µg/mL (p<0.001) and 100 µg/mL (p<0.0001), and between 50 µg/mL and 100 µg/mL (p<0.01). Cetuximab 50 µg/mL inhibited cell invasion through the MatrigelTM compared with SCC-4 control cells (p<0.01). Cetuximab 50 µg/mL affected the organization of the actin cytoskeleton. Cetuximab has an inhibitory effect on actin cytoskeleton organization, cell migration and invasion, suggesting that Cetuximab treatment can be important to avoid oral squamous cell carcinoma metastasis.


Subject(s)
Antineoplastic Agents, Immunological/pharmacology , Carcinoma, Squamous Cell/drug therapy , Cell Movement/drug effects , Cetuximab/pharmacology , Mouth Neoplasms/drug therapy , Neoplasm Invasiveness/prevention & control , Actin Cytoskeleton/drug effects , Actin Cytoskeleton/pathology , Carcinoma, Squamous Cell/pathology , Cell Line, Tumor , Humans , Mouth Neoplasms/pathology , Neoplasm Invasiveness/pathology
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15.
Rev Bras Med ; 25(2): 149-51, 1968 Feb.
Article in Portuguese | MEDLINE | ID: mdl-5656170
19.
Rev Bras Med ; 23(6): 445-6, 1966 Jun.
Article in Portuguese | MEDLINE | ID: mdl-5997409
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