ABSTRACT
Tranexamic acid (TXA) is an essential procoagulant drug used in various intra- and postoperative situations. Its efficacy and safety profile in obese cases undergoing laparoscopic sleeve gastrectomy (LSG) is still unresolved. Therefore, this meta-analysis evaluated and investigated the current intra- and postoperative effects and hazards of TXA on patients undergoing LSG. As for methodology, Web of Science, Cochrane Library, Scopus, and PubMed were thoroughly searched for relevant studies. Retrieved results were prepared for screening through Endnote, helping to identify eligible studies. Relevant patient characteristics and outcomes were extracted. The methodological quality of the relevant studies was appraised using the respected appraisal tool. Six studies of different designs were enrolled, comprising 753 cases that underwent LSG and administered TXA. Their mean BMI and age went from 37.3 to 56.25 kg/m2 and 33.5 to 43.25 years, respectively. Tranexamic acid significantly linked to reduction in intraoperative bleeding instances, operative blood loss, and operative duration, compared to placebo ((RR = 0.66, 95% CI [0.44, 0.98], P=0.04, I2 = 81%); (MD = -39.64, 95%CI [-75.49, -3.78], P=0.03, I2=94%); (MD=-5.84, 95%CI [-9.62, -2.05], P=0.003, I2=73%)). Tranexamic acid also significantly showed superiority regarding postoperative bleeding events and duration of hospitalization compared to the control group ((RR= 0.45, 95%CI [0.29, 0.69], P=0.0002, I2 =0%); (MD=-0.24, 95%CI [-0.32, -0.17], P< 0.0000, I2 =0%)). Moreover, follow-up of the enrolled patients for a minimum of three to six months resulted in no reported thromboembolic instances, suggesting a negligible risk for thromboembolism among patients undergoing LSG and receiving TXA. In conclusion, tranexamic acid demonstrates a robust safety and efficacy profile for its use in patients undergoing LSG, with no reported instances of thromboembolism. Variations in TXA administration regimens, bleeding definitions, procedural techniques, and potential confounding medications could not be accounted for, necessitating additional large-scale RCTs to address and bridge knowledge gaps.
ABSTRACT
Introduction Glaucoma can be considered a heterogeneous group of diseases with characteristic progressive optic neuropathy, which causes the development of visual field dysfunctions and irreversible blindness. Glaucoma is the most prevalent cause of irreversible blindness worldwide. Aim This study aimed to assess the awareness and knowledge of glaucoma and its associated risk factors among the adult population in Jazan, Saudi Arabia, in 2022. Methods A community-based cross-sectional study was conducted with 384 participants aged 40 years and above in the Jazan region. A convenience sampling technique was adopted to obtain the target sample size. Data were collected using a self-administered electronic questionnaire on Google Forms. Results A majority (73.1%) of the 387 respondents to the questionnaire were in the age group of 40-50 years, with the average age being 47.43 years. No statistically significant difference was found between different age groups' level of knowledge (p=0.769). In addition, the difference between levels of knowledge based on participants' residence was also statistically insignificant (p=0.387). Of the participants who were not diagnosed with glaucoma, 55% had poor knowledge of glaucoma; however, only 3.10% of the participants diagnosed with glaucoma had poor knowledge of the condition. Consequently, there was a statistically significant difference between participants' levels of knowledge based on their diagnosis of glaucoma (p=0.04). Conclusion The study revealed low knowledge and awareness levels regarding glaucoma among adults aged 40 years and above in the Jazan region.
