Emergence of concurrent infections with colistin-resistant ESBL-positive Klebsiella pneumoniae and OXA-23-producing Acinetobacter baumannii sensitive to colistin only in a Romanian cardiac intensive care unit.

We report the emergence and analysis of a cluster of concurrent infections/colonisations with colistin-resistant Klebsiella pneumoniae and OXA-23 carbapenemase-producing Acinetobacter baumannii in patients who had undergone cardiac surgery. We describe the emergence of colistin-resistant K. pneumoniae harbouring blaCTX-M-15, blaSHV-11, blaOXA-1, blaTEM-1 beta-lactamases and aac(6')-Ib-cr fluoroquinolone resistance. Colistin-resistant K. pneumoniae infections (pneumonia, wound infection, urinary tract infections and bacteraemia) occurred in critically ill patients previously treated with colistin for post-surgery infections with carbapenem-resistant Pseudomonas aeruginosa and/or A. baumannii. Although the cause of death could not be directly attributed to a single pathogen, three patients co-infected/colonised with K. pneumoniae, P. aeruginosa and/or A. baumannii died, whilst a fourth patient who had a mono-microbial infection with colistin-resistant K. pneumoniae only survived. The use of mobile intubation equipment in patients that shared the same ward, the clustering of cases over a short period of time, as well as the pulsed-field gel electrophoresis (PFGE) data all suggest cross-contamination between patients, either through equipment or by staff contact transmission. This report presents the 'worst-case scenario' where concurrent infection/colonisation with pathogens exhibiting resistance to different types of last-resort antimicrobials occurred in some of the most debilitated intensive care unit (ICU) patients.

Subacute fungal endocarditis due to Acremonium spp: a case study and review of the literature.

A 52 years old patient is hospitalized in June 2007 in the Cardiology Clinic of Cardiovascular Diseases Medical Institute in Iasi with suspected subacute infectious endocarditis. Echocardiography shows mobile vegetation on the pulmonary valve. Acremonium spp is isolated from blood cultures after 2 weeks of incubation. The patient was treated with fluconazole, but died after 3 months due to renal failure.

[Extracorporeal shock wave lithotripsy (ESWL) can be done for lithiasic patients with cardiac arrhythmias with a lithotriptor without ECG triggering system--the experience of Iasi Urological Department]. / Litotritia extracorporeala la pacientii cu tulburari de ritm. Experienta Clinicii Urologice Iasi.

The recommendations for spark gap lithotripters include that the shock waves must be delivered according to the ECG, avoiding the discharge during the refractory part of the heart activity. The lithotripters we have in our department does not have from the factory an ECG correlated triggering system. Observing that ESWL for patients without heart problems did not induced arrhythmias, we decide to perform this procedure under strict cardiologic supervision to the patients having arrhythmias (chronic fibrillation, chronic atrial fibrillation, supraventricular arrhythmias, supraventricular premature beats, ventricular premature beats, ventricular tachycardia). All the ESWIL sessions did not have any major incidents and all the patients return home safe, without any changes of the cardiac medication. Even we did not notice any aggravation of the cardiac arrhythmias during ESWL we consider that the careful monitoring of the patients by the cardiologist is necessary during the procedure, most of all when the spark gap lithotripter has not an ECG triggering system.

[Cardiac amyloidosis. A case report]. / Amiloidoza cardiaca. Prezentare de caz.

The paper presents the morphoclinical picture in cardiac amyloidosis to a 50 years old man admitted at Iasi Cardiology Center with progressive chronic cardiac failure, the patient having recent history of restrictive cardiomyopathy. It was made a complete cardiovascular evaluation including the right cardiac catheterization for endomyocardial biopsy. The biopsy specimens were fixed in buffered 10 % formalin, followed by routine paraffin embedding, and were stained with haematoxylin-eosin, elastic Van Gieson and sulphated blue Alcian for amyloid evaluation. The amyloid deposits were evidentiated in the interstitium and into vascular walls of the biopsy, pointing the importance of the morphological exam for amyloidosis diagnosis.

[ANF--atrial natriuretic factor]. / FNA--factorul natriuretic atrial.

Is produced at the right atrium and is acting upon four types of receptors. The main effects of ANF are: renal effects, by rapid increasing and prolongation of glomerular filtration; neuroumoral effects--the inhibition of renin-angiotensin system and of the release of aldosterone; effects upon the vascular wall, with vasodilatation; another effect is the regulation of the hydrosalin balance. The therapeutical endpoints of ANF are related to its action in some diseases like: cardiac failure, arterial hypertension, myocardia infarction, paroxysmal arrhythmias; in some of them it is a very fiable predictive marker. ANF represents o neuroumoral mechanism which play an important role in functional regulation of the cardio-vascular system.

[The effect of rehabilitative treatment on left ventricular performance in myocardial infarct patients in the convalescent phase]. / Efectul tratamentului recuperator asupra performantei ventriculare stângi la bolnavii cu infarct miocardic în faza de convalescenta.

There have been studied the left ventricular performance at 71 patients (66 B/5 F) with myocardial infarction during the convalescence period, admitted in the Department of Clinical Rehabilitation in a period of time between 01.01.1992-31.10.1993. Mean age was 49.9 +/- 4.3 years. Most of the patients had antero-septal (33 patients--46%) and posteroinferior (29 patients--41%) myocardial infarction. The left ventricular performance was assessed by the study of exercise electrocardiography (TTI), of the systolic intervals using the Weissler equations and echocardiography (M-mode and 2D). After the period pf training (21 days), we saw a significant reduction of TTI at the same step of the test. The systolic intervals significantly modified after the training were PEVS (p < 0.025), PEP/PEVS (p < 0.025), EF (p < 0.025). EF and SF measured echographically do not indicate significant differences after the training. There are not important improvements of the wall motion disorders at the end of the period.