ABSTRACT
The effect of one-month-long inhalation exposure of male rats to sulphureous anhydrate, phenol, ammonia or to the mixture of these substances with formaldehyde and lead acetate, on the parameters of spermatogenesis was studied. The exposure of animals to sulphureous anhydrate or to the mixture indicated above resulted in the asynchronization of spermatogenic cycle, which was more significant than that caused by the separate application of substances studied. This mixture induced a 20% reduction in the number of tubules, containing spermatogonia, and a 20-30% increase in the number of tubules, containing spermatozoa. The structural and functional study of spermatogenic epithelium, considering stages of spermatogenic cycle, indicated that some cell populations form associations that are targets for the toxic agents studied.
Subject(s)
Environmental Monitoring/methods , Environmental Pollutants/toxicity , Spermatogenesis/drug effects , Testis/drug effects , Animals , Drug Synergism , Formaldehyde/toxicity , Male , Organometallic Compounds/toxicity , Phenol/toxicity , Quaternary Ammonium Compounds/toxicity , Rats , Seminiferous Tubules/drug effects , Seminiferous Tubules/pathology , Sulfur Dioxide/toxicity , Testis/pathologyABSTRACT
The data of the morphological studies of liver of animals subjected to chronic (3 months long) intoxication with different chemical substances (ammonium nitrogen, nitrite nitrogen, fluorine, chromium, arsenic) are presented. The xenobiotics tested induced stereotyped responses in liver which differed in their intensity and the extent of hemomicrocirculatory and inflammatory-destructive alterations. Most pronounced reactive changes were found in animals exposed to arsenic compounds, while sodium nitrate caused practically no destructive changes in hepatocytes.
