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1.
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Adams, Alan D; Hu, Zao; von Langen, Derek; Dadiz, Adonis; Elbrecht, Alex; MacNaul, Karen L; Berger, Joel P; Zhou, Gaochao; Doebber, Thomas W; Meurer, Roger; Forrest, Michael J; Moller, David E; Jones, A Brian.
Bioorg Med Chem Lett ; 13(19): 3185-90, 2003 Oct 06.
Article in English | MEDLINE | ID: mdl-12951090

ABSTRACT

A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.


Subject(s)
Mandelic Acids/pharmacology , Receptors, Cytoplasmic and Nuclear/agonists , Transcription Factors/agonists , Animals , Mandelic Acids/metabolism , Mice , Mice, Inbred C57BL , Mice, Transgenic , Protein Binding/drug effects , Protein Binding/physiology , Rats , Receptors, Cytoplasmic and Nuclear/metabolism , Transcription Factors/metabolism
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