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1.
J Pharm Belg ; (3): 24-9, 2012 Sep.
Article in French | MEDLINE | ID: mdl-23697093

ABSTRACT

Medication management in home care is an error prone process. In a small pilot project in Flanders, community pharmacists collaborated with physicians and home care nurses through a shared electronic care plan, to optimize the medication management of their home care patients. The pilot project shows that GPs and nurses are positive about the possible contribution of the pharmacist in medication management of home care patients. A larger follow up study is necessary to further identify possible roles of pharmacists in home care and to show related health benefits.


Subject(s)
Community Pharmacy Services , Drug Therapy/methods , Home Care Services , Pharmacists , Cooperative Behavior , Drug-Related Side Effects and Adverse Reactions , Humans , Patient Care , Patient Care Team , Pharmaceutical Preparations/administration & dosage , Pilot Projects
2.
Aliment Pharmacol Ther ; 21(2): 187-94, 2005 Jan 15.
Article in English | MEDLINE | ID: mdl-15679769

ABSTRACT

AIM: To evaluate, using isotope techniques, the in vivo effectiveness of a pH-dependent colonic delivery system. METHODS: In order to dispose of differently labelled substrates for measurement of orocaecal transit time, inulin-14C-carboxylic acid was evaluated as an alternative substrate to inulin and lactose-13C-ureide. Secondly, the time of release of 13C- and 15N-urea from the colonic delivery system was compared with the orocaecal transit time, measured using inulin and inulin-14C-carboxylic acid. This study was repeated after a 2-week lactulose intake period. RESULTS: The orocaecal transit time determined using inulin-14C-carboxylic acid (398 min) was not significantly different from the orocaecal transit time determined using inulin (420 min) or lactose-13C-ureide (396 min). Before lactulose intake, the 13CO2 excretion time was 358 min and the orocaecal transit times determined with the inulin-14C-carboxylic acid and inulin breath test were 376 and 375 min respectively. After lactulose, the 13CO2 excretion time was 383 min and orocaecal transit times were 354 min for inulin-14C-carboxylic acid and 392 min for inulin. A highly significant correlation was found. Good agreement was found between the urinary 15N excretion and the appearance of 13CO2 in breath. CONCLUSION: Isotope techniques provide an excellent non-invasive tool for the in vivo evaluation of a colonic delivery system.


Subject(s)
Carbon Radioisotopes , Carboxylic Acids , Colon/physiology , Drug Delivery Systems/standards , Gastrointestinal Transit/physiology , Inulin , Nitrogen Radioisotopes , Adult , Breath Tests/methods , Capsules , Carbon Dioxide/metabolism , Drug Combinations , Female , Humans , Hydrogen-Ion Concentration , Male , Urea/metabolism , Urea/urine
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