1.
Bioorg Med Chem Lett
; 12(13): 1727-30, 2002 Jul 08.
Article
in English
| MEDLINE
| ID: mdl-12067547
ABSTRACT
The solid-phase synthesis of substituted 1,2,4-triazoles tethered to a 4-mercaptopyrrolidine core 1 is described. This novel class of non-peptidic, Zn(2+) metallo-protease inhibitors was found to have inhibitory activity for the endothelin converting enzyme (ECE-1). The SAR of the substitution pattern in 1 is discussed.
