Subject(s)
Erythrocyte Indices , Intensive Care Units/statistics & numerical data , Pancreatitis/diagnosis , Severity of Illness Index , Acute Disease , Adult , Aged , Female , Humans , Length of Stay/statistics & numerical data , Male , Middle Aged , Pancreatitis/blood , Prognosis , Retrospective Studies , Sensitivity and SpecificitySubject(s)
Abdominal Pain/diagnostic imaging , Deglutition Disorders/etiology , Subclavian Artery/diagnostic imaging , Tomography, X-Ray Computed , Abdominal Pain/diet therapy , Abdominal Pain/etiology , Abdominal Pain/pathology , Adult , Deglutition Disorders/diagnostic imaging , Deglutition Disorders/diet therapy , Deglutition Disorders/pathology , Female , Humans , Subclavian Artery/abnormalities , Treatment Outcome , Vomiting , Weight LossABSTRACT
We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.
Subject(s)
Diabetes Mellitus, Type 2/genetics , Polymorphism, Single Nucleotide , Transcription Factor 7-Like 2 Protein/genetics , Adult , Aged , Alleles , Arabs , Diabetes Mellitus, Type 2/metabolism , Female , Gene Frequency , Genetic Predisposition to Disease , Genome-Wide Association Study , Haplotypes , Humans , Lebanon , Linkage Disequilibrium , Male , Middle Aged , Transcription Factor 7-Like 2 Protein/metabolismABSTRACT
We investigated the association of CDKAL1 (rs7754840 and rs7756992) and CDKN2A/2B (rs10811661) variants with T2DM. Higher MAF of rs7754840 and rs7756992 were seen in patients, and both were associated with T2DM under additive, dominant, and recessive models. CDKAL1 rs7754840 and rs7756992, but not CDKN2A/2B rs10811661, are associated with T2DM in Lebanese.
