ABSTRACT
Five patients with clinically inoperable bronchial squamous cell carcinoma were treated with infusions of 10 mg Mitomycin-C in the bronchial artery feeding the tumour, in an attempt to make inoperable bronchogenic carcinoma resectable. One patient had only one treatment while the other four had the infusion repeated three times with an interval of two weeks between treatments. In all cases there was a marked regression of the tumour. Four patients had the tumour resected 1-2 weeks following the last treatment and two of these are still alive 2 1/2 and 4 years later. The other two patients died 14 and 22 months following the initiation of the treatment. The fifth patient developed serious adverse effects to the drug that only slowly subsided. He died 5 1/2 months following the initiation of the treatment and his tumour was not resected. This limited study demonstrates the possibility of making certain inoperable patients with bronchogenic carcinoma operable, but it also stresses the problems of a correct preoperative staging.
Subject(s)
Carcinoma, Squamous Cell/drug therapy , Lung Neoplasms/drug therapy , Mitomycins/therapeutic use , Aged , Bronchial Arteries , Carcinoma, Squamous Cell/diagnostic imaging , Carcinoma, Squamous Cell/surgery , Combined Modality Therapy , Humans , Infusions, Intra-Arterial , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/surgery , Middle Aged , Mitomycin , Mitomycins/administration & dosage , Preoperative Care , RadiographySubject(s)
Lung Neoplasms/surgery , Melanoma/surgery , Adult , Female , Humans , Lung Neoplasms/secondary , Male , Melanoma/secondary , Middle Aged , Pneumonectomy , Prognosis , Retrospective StudiesABSTRACT
Seven patients with squamous cell carcinomas of the lung and nodular metastases underwent Daniels' biopsy and cannulation of the thoracic duct. Lymph specimens obtained by aspiration the day after catheter insertion were examined by cytologic and cytogenetical techniques, including chromosome banding methods. In five of the seven cases maligant cells could be detected by karyotype analysis, whereas standard cytologic examinations yielded no positive diagnoses. This indicates that chromosome analysis is applicable as a diagnostic tool in lymph fluid.
Subject(s)
Carcinoma, Squamous Cell/pathology , Chromosome Aberrations , Lung Neoplasms/pathology , Lymph/cytology , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/genetics , Cytodiagnosis , False Negative Reactions , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/genetics , Lymphatic Metastasis , Thoracic DuctSubject(s)
Aortic Aneurysm , Aortic Dissection , Aortic Dissection/diagnosis , Aortic Dissection/mortality , Aortic Dissection/surgery , Antihypertensive Agents/therapeutic use , Aortic Aneurysm/diagnosis , Aortic Aneurysm/mortality , Aortic Aneurysm/surgery , Diagnosis, Differential , Humans , Myocardial Infarction/diagnosisSubject(s)
Heart Neoplasms/diagnosis , Myxoma/diagnosis , Adult , Angiocardiography , Echocardiography , Heart Atria , Heart Neoplasms/surgery , Humans , Male , Mitral Valve , Myxoma/surgeryABSTRACT
Nine patients with various types of severe glomerulonephritis were treated with drainage of the thoracic duct (n=8) and/or plasmapheresis (n=6) without the use of pharmacological immunosuppression. In most of the patients treatment produced a prompt temporary regression of albuminuria and creatininemia. In one patient renal function was substantially improved 8 months after the last period of treatment, in 2 patients the progress of the uremia was probably retarded. In the remaining 6 patients treatment had no obvious effect on the course of the illness. Drainage of the thoracic duct and plasmapheresis may be of benefit in the treatment of glomerulonephritis, but their proper utilization requires further studies.
Subject(s)
Drainage , Glomerulonephritis/therapy , Plasmapheresis , Thoracic Duct/surgery , Adolescent , Adult , Aged , Albuminuria , Child , Creatinine/blood , Female , Follow-Up Studies , Humans , Male , Middle AgedABSTRACT
At scanning electron microscopy of cells from the lymph of the thoracic duct, collected by cannulation of patients with malignant tumours of different types, lymphocytes and red blood cells were found, but few malignant cells. The latter came from patients with pulmonary carcinoma and mammary carcinoma with lung metastases. Various abnormal shapes of the red blood cells were observed, possibly due to extrinsic factors such as administered drugs of abnormal metabolites from the malignant disease. The lymphocytes had no consistent pathologic shape, but appeared to act as immunologic, active cells against the malignant cells in the thoracic lymph.
