ABSTRACT
A method for preparation of autologous 131J-tagged human fibrinogen is demonstrated. In vitro the preparation is characterized by content of fibrinogen, protein, plasminogen, clottability and molecular weight. Total plasma radioactivity, specific radioactivity, non-protein-bound radioactivity, biologic half-life and the local activity at the thrombus define the properties in vivo. With the above criteria autologous 131-J-tagged human fibrinogen was shown to be useful for early diagnosis of venous thrombosis.
Subject(s)
Fibrinogen/analysis , Thrombosis/blood , Blood Coagulation Tests/methods , Humans , Iodine Radioisotopes , Time FactorsSubject(s)
Hemodynamics , Hypertension, Renal/physiopathology , Kidney Failure, Chronic/complications , Adult , Blood Pressure Determination , Blood Volume Determination , Female , Forearm/blood supply , Heart/physiopathology , Humans , Hypertension, Renal/diagnosis , Hypertension, Renal/etiology , Male , Middle Aged , Plethysmography, Impedance , Veins/physiopathologyABSTRACT
In 10 normotensive subjects intravenous infusion of angiotensin was followed by a significant increase in the arterial pressure, total peripheral resistance, central venous pressure and by a marked reduction of the intravascular forearm volume and venous distensibility. Forearm circulation time was shortened. The cardiac index, heart rate, forearm vascular resistance and the forearm blood flow did not change significantly.
Subject(s)
Angiotensin II/pharmacology , Hemodynamics/drug effects , Veins/drug effects , Adolescent , Adult , Angiotensin II/administration & dosage , Blood Pressure/drug effects , Blood Volume/drug effects , Cardiac Output/drug effects , Forearm/blood supply , Humans , Infusions, Parenteral , Regional Blood Flow/drug effects , Vascular Resistance/drug effects , Vasodilator AgentsABSTRACT
1. L6150 is a highly effective vasodilator which produces an acute reduction of blood pressure when administered intravenously. 2. This is due entirely to a decrease in total peripheral vascular resistance. 3. On oral administration it can effectively lower blood pressure in mild hypertension and is effective in combination with other hypotensive agents with different mechanisms of action.
Subject(s)
Ethanolamines/therapeutic use , Hypertension/drug therapy , Pyridazines/therapeutic use , Vasodilator Agents/therapeutic use , Administration, Oral , Clinical Trials as Topic , Ethanolamines/administration & dosage , Humans , Injections, Intravenous , Pyridazines/administration & dosage , Vascular Resistance/drug effects , Vasodilator Agents/administration & dosageABSTRACT
As long as there is no satisfactory prophylaxis for thrombosis, the radioiodine-fibrinogen test is a good supplement for the supervision of patients with a "high thrombosis risk" since the clinical symptomatology is not specific enough and phlebography cannot be used to extensively. The risk of hepatitis can be reduced when the selection of spenders is large enough. As a radionuclide, 125iodine does not appear to be any less effective than 131iodine. The postoperative injection is preferred to the preoperative injection.
