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1.
Heredity (Edinb) ; 108(5): 507-14, 2012 May.
Article in English | MEDLINE | ID: mdl-22108628

ABSTRACT

Global mitochondrial DNA (mtDNA) data indicates that the dog originates from domestication of wolf in Asia South of Yangtze River (ASY), with minor genetic contributions from dog-wolf hybridisation elsewhere. Archaeological data and autosomal single nucleotide polymorphism data have instead suggested that dogs originate from Europe and/or South West Asia but, because these datasets lack data from ASY, evidence pointing to ASY may have been overlooked. Analyses of additional markers for global datasets, including ASY, are therefore necessary to test if mtDNA phylogeography reflects the actual dog history and not merely stochastic events or selection. Here, we analyse 14,437 bp of Y-chromosome DNA sequence in 151 dogs sampled worldwide. We found 28 haplotypes distributed in five haplogroups. Two haplogroups were universally shared and included three haplotypes carried by 46% of all dogs, but two other haplogroups were primarily restricted to East Asia. Highest genetic diversity and virtually complete phylogenetic coverage was found within ASY. The 151 dogs were estimated to originate from 13-24 wolf founders, but there was no indication of post-domestication dog-wolf hybridisations. Thus, Y-chromosome and mtDNA data give strikingly similar pictures of dog phylogeography, most importantly that roughly 50% of the gene pools are shared universally but only ASY has nearly the full range of genetic diversity, such that the gene pools in all other regions may derive from ASY. This corroborates that ASY was the principal, and possibly sole region of wolf domestication, that a large number of wolves were domesticated, and that subsequent dog-wolf hybridisation contributed modestly to the dog gene pool.


Subject(s)
Animals, Domestic/genetics , Dogs/genetics , Evolution, Molecular , Wolves/genetics , Y Chromosome/genetics , Animals , Animals, Domestic/classification , Asia, Southeastern , Chromosomes, Human, Y/genetics , DNA, Mitochondrial/genetics , Dogs/classification , Female , Genetic Variation , Haplotypes , Humans , Male , Molecular Sequence Data , Phylogeny , Wolves/classification
2.
Scand J Soc Med ; 22(1): 58-67, 1994 Mar.
Article in English | MEDLINE | ID: mdl-8029668

ABSTRACT

Epidemiological studies have demonstrated an excess mortality caused by cancer and cardiovascular diseases among the workers employed at a smeltery in Northern Sweden. The aim of this paper is to elucidate the attitudes of the smelter workers to their working environment and to their health and to examine how these attitudes have changed over time. Moreover, in the analysis, we have sought explanations in the norm systems surrounding the workers and the changes in these. Interviews were carried out with 40 employees and previous employees at the smeltery. The interviewees were strategically chosen to reflect the development process of these norms within the company from its inception in the 1920s and onwards. We have attempted to describe the differences in behavioural patterns and norm expectations which characterize different periods in the history of the smeltery using four ideal type categories; the heroic man, the working-class man, the independent man and the anomic man. The workers' reactions to the norm systems have shifted gradually from conformity to indifference. The degree of individuality during these decades could be shown as a u-shaped curve.


Subject(s)
Attitude to Health , Cardiovascular Diseases/prevention & control , Metallurgy , Neoplasms/prevention & control , Occupational Diseases/prevention & control , Social Values , Cardiovascular Diseases/mortality , Copper , Environment , Health Behavior , Humans , Male , Neoplasms/mortality , Occupational Diseases/mortality , Risk Factors , Self Concept , Surveys and Questionnaires , Sweden/epidemiology , Time Factors , Workplace
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