1.
Dalton Trans
; 45(28): 11362-8, 2016 Jul 28.
Article
in English
| MEDLINE
| ID: mdl-27331604
ABSTRACT
Platinum(ii) N-heterocyclic carbene complexes have been oxidized by bromine or iodobenzene dichloride to provide the fully characterised corresponding platinum(iv) NHC complexes. Antiproliferative activities of Pt(iv) NHC complexes were assayed against several cancer cell lines and the results were correlated with respect to their stability. Mechanistic investigations revealed that mitochondrial dysfunction and ROS production were associated with the cytotoxic process induced by these compounds.
Subject(s)
Heterocyclic Compounds/chemical synthesis , Heterocyclic Compounds/pharmacology , Methane/analogs & derivatives , Platinum Compounds/chemical synthesis , Platinum Compounds/pharmacology , Cell Line, Tumor , Cell Proliferation/drug effects , Humans , Methane/chemistry , Mitochondria/drug effects
2.
Clin Investig
; 72(3): 214, 1994 Feb.
Article
in English
| MEDLINE
| ID: mdl-8012165
Subject(s)
Critical Illness , Endothelins/blood , Female , Humans , Male , Middle Aged , Severity of Illness Index
3.
Z Kardiol
; 80 Suppl 8: 103-4, 1991.
Article
in German
| MEDLINE
| ID: mdl-1796626
