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1.
Eur J Med Chem ; 45(3): 1225-9, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20036446

ABSTRACT

Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC(50) values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.


Subject(s)
Carbonic Anhydrase II/antagonists & inhibitors , Carbonic Anhydrase Inhibitors/chemistry , Carbonic Anhydrases/chemistry , Sulfonamides/pharmacology , Ammonia/chemistry , Animals , Carbonic Anhydrase Inhibitors/pharmacology , Cattle , Enzyme Activation/drug effects , Gases , Humans , Molecular Structure , Sheep , Sulfonamides/chemical synthesis , Sulfonamides/chemistry
2.
J Org Chem ; 70(21): 8327-31, 2005 Oct 14.
Article in English | MEDLINE | ID: mdl-16209574

ABSTRACT

2-trifluoromethylquinolines 5 are synthesized in high yields using a perfluoroalkylated gem-iodoacetoxy derivative 3 and arylamines 4. The intermediate of this reaction, 2-trifluoromethyl-1,5-diazapentadiene compound 6, was isolated. The procedures are easy, and yields are in general high. This sequence represents a valuable new synthesis of substituted 2-trifluoromethylquinolines and of 2-trifluoromethyl-diazapentadienes (vinamidine compounds).


Subject(s)
Aniline Compounds/chemical synthesis , Quinolines/chemical synthesis , Vinblastine/analogs & derivatives , Vinblastine/chemical synthesis , Aniline Compounds/chemistry , Cyclization , Molecular Structure , Quinolines/chemistry , Stereoisomerism
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