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Fitoterapia ; 152: 104942, 2021 Jul.
Article in English | MEDLINE | ID: mdl-34029655

ABSTRACT

Laggera pterodonta (DC.) Benth, a folk herb widely distributes in southwest China, especially in Yunnan Province, demonstrates anti-pathogenic microorganisms, anti-inflammatory, inhibition of Helicobacter pylori activities in vitro et al. Interestingly, previous studies have shown that pterodontic acid (1), a eudesmane-type sesquiterpene isolated from L. pterodonta (DC.), displays excellent selective antiviral activity to H1N1 subtype of influenza A virus. At the same time, our group also discovered that the antiviral activity of 1 was relatively close to that activity of post-marketed ribavirin. Therefore, we consider that the synthesis of pterodontic acid (1) derivatives and evaluation of their anti-influenza A virus (H1N1) activities is of potential clinical significance. In this manuscript, a series of pterodontic acid derivatives were prepared and demonstrated significantly improved anti-influenza A virus (H1N1) activities, providing more opportunities for the treatment of respiratory viral diseases.


Subject(s)
Antiviral Agents/pharmacology , Asteraceae/chemistry , Influenza A Virus, H1N1 Subtype/drug effects , Sesquiterpenes/pharmacology , Animals , Antiviral Agents/chemical synthesis , China , Dogs , Madin Darby Canine Kidney Cells , Molecular Structure , Sesquiterpenes/chemical synthesis
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