ABSTRACT
Forty four patients with portal hypertension of varying etiology, including 25 patients with an acute episode of variceal bleeding and 19 with past history of hematemesis, were followed up for eighteen months following endoscopic variceal sclerotherapy (EVS). Of 11 patients in Child's A group, two died of acute bleed, three were subjected to shunt surgery and the remaining six survived the follow-up period. Ten of 11 cases in Child's C did not survive more than six months in spite of sclerotherapy. We conclude that rebleed and death due to rebleed following EVS occur more commonly in patients with poor hepatic reserve (Child's C) as compared to patients in Child's A and B.
Subject(s)
Esophageal and Gastric Varices/therapy , Gastrointestinal Hemorrhage/therapy , Liver Cirrhosis/therapy , Sclerotherapy , Child , Child, Preschool , Endoscopy , Humans , Hypertension, Portal/therapy , India , Liver Cirrhosis/mortality , Prospective Studies , SurvivalSubject(s)
Campylobacter fetus/isolation & purification , Diarrhea/microbiology , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. The compound was generally well tolerated; mild giddiness was observed in nine patients and severe giddiness was present in one patient. Clinical and biochemical monitoring revealed no other toxicity of the compound.
Subject(s)
Aniline Compounds/therapeutic use , Anthelmintics/therapeutic use , Diphenylamine/therapeutic use , Hookworm Infections/drug therapy , Thiocyanates/therapeutic use , Ancylostoma/drug effects , Anthelmintics/administration & dosage , Clinical Trials as Topic , Diphenylamine/administration & dosage , Diphenylamine/analogs & derivatives , Drug Evaluation , Feces/parasitology , Female , Humans , Isothiocyanates , Male , Necator/drug effects , Parasite Egg Count , Thiocyanates/administration & dosageABSTRACT
A double-blind placebo controlled study was carried out in 24 healthy male volunteers to assess the nature and extent of any gastro-intestinal damage caused by the short-term administration of flurbiprofen (300 mg/day), aspirin (2.1 g/day), and phenylbutazone (600 mg/day). Fibre-optic endoscopic examinations were made before and after 7-days' treatment by 3 observers. The results showed that aspirin produced severe and extensive damage. The changes seen with phenylbutazone were less severe than with aspirin but more marked than with flurbiprofen. Flurbiprofen was found to have produced minor changes which tended to be localized. The histopathological findings correlated well with the endoscopic observations.
Subject(s)
Aspirin/adverse effects , Flurbiprofen/adverse effects , Gastrointestinal Diseases/chemically induced , Phenylbutazone/adverse effects , Propionates/adverse effects , Adult , Clinical Trials as Topic , Double-Blind Method , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/pathology , Gastroscopy , Humans , Male , PlacebosABSTRACT
This paper presents our experience with mebendazole, a new broad-spectrum anthelmintic, in 91 cases with ascariasis, 71 cases with necatoriasis 54 cases with trichuriasis and 10 cases with T. saginata infection. Various dosage schedules were evaluated. In ascariasis, a single dose of 200 mg was effective in totally clearing the infection in 100 per cent cases. In necatoriasis 200 mg twice daily for four days was found to be the most effective dose. With this dose total eradication of the infection was seen in 92 per cent cases. In trichuriasis, 200 mg twice daily for four days totally eradicated the infection in 90 per cent cases. In T. saginata infection, the drug was totally ineffective. The anthelminitic activity of the drug was demonstrated by the recovery of roundworms, hookworms and whipworms from the stools. The drug was well tolerated. No side effects or toxic effects were seen in any of the cases.
