ABSTRACT
Dose-response for micronuclei in cytokinesis-blocked lymphocytes after in vitro irradiation of whole blood from 3 donors with Co-60 gamma-rays in the range 0-5.0 Gy was established. The numerical relationship between radiation induced chromosomal aberrations, and micronuclei is also examined. An increased frequency of micronuclei following low doses of gamma-irradiation is reported from a study of 41 radiation workers.
Subject(s)
Lymphocytes/radiation effects , Micronuclei, Chromosome-Defective/radiation effects , Adult , Chromosome Aberrations , Cobalt Radioisotopes , Dose-Response Relationship, Radiation , Female , Gamma Rays , Humans , Lymphocytes/ultrastructure , Male , Occupational Exposure , Radiation MonitoringABSTRACT
A dose-response curve has been obtained for the induction of chromosome aberrations in human lymphocytes from blood acutely irradiated with 60Co gamma-rays in a dose range of 0.098-4.89 Gy. This curve has been used for biological dose estimation for 21 cases of known or suspected accidental overexposure of Turkish radiation workers.
