ABSTRACT
No disponible
Subject(s)
Child, Preschool , Male , Humans , Urticaria/etiology , Histamine H1 Antagonists/therapeutic use , Spain/epidemiology , Cosmetics/adverse effects , Skin TestsABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Omeprazole/adverse effects , Piroxicam/adverse effects , Pruritus/etiologyABSTRACT
We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to various cytokines increased CD62L expression only in the more differentiated CB and BM CD34+/CD38+ cells.
Subject(s)
Antigens, CD , Bone Marrow Cells/cytology , Cell Adhesion Molecules/analysis , Fetal Blood/cytology , Hematopoietic Stem Cells/chemistry , ADP-ribosyl Cyclase , ADP-ribosyl Cyclase 1 , Antigens, CD34/analysis , Antigens, Differentiation/analysis , Bone Marrow Cells/chemistry , Fetal Blood/chemistry , Flow Cytometry , Humans , L-Selectin/analysis , Lymphocyte Function-Associated Antigen-1/analysis , Membrane Glycoproteins , NAD+ Nucleosidase/analysisABSTRACT
BACKGROUND AND OBJECTIVE: Granulocyte colony-stimulating factor (G-CSF) has been shown to improve the neutropenic status of patients with bone marrow failure. The side effects in prolonged treatment still need to be determined. DESIGN AND METHODS: We have studied the efficacy and the long-term side effects of G-CSF in four patients with Fanconi's anemia and severe neutropenia. RESULTS: Three patients responded with an increase in their absolute neutrophil count; neither improvement in platelet count and hemoglobin concentration nor effect on transfusion requirements was seen. CFU-GM and BFU-E were undetectable before, during and after treatment. Responders showed an important reduction in number and severity of infections, with a marked improvement of clinical status. The fourth patient developed acute myeloid leukemia after 4 weeks of G-CSF treatment. During maintenance, one patient was treated with G-CSF for 18 months, until she received bone marrow transplantation, without presenting side effects. In the second responding patient G-CSF treatment was stopped because of appearance of immature cells in peripheral blood and myeloid blasts in bone marrow. The third responding patient presented immature peripheral myeloid cells during the third year of G-CSF treatment: disappearance of immature cells was observed after G-CSF reduction. In two cases FISH analysis revealed monosomy 7 after G-CSF treatment. INTERPRETATION AND CONCLUSIONS: G-CSF use results in an improvement of clinical status, but long term administration may cause adverse experiences and requires a close hematological monitoring.
Subject(s)
Fanconi Anemia/drug therapy , Granulocyte Colony-Stimulating Factor/therapeutic use , Neutropenia/drug therapy , Adolescent , Child , Fanconi Anemia/complications , Female , Humans , Male , Neutropenia/etiology , Recombinant ProteinsABSTRACT
von Willebrand type I disease is an hereditary coagulation disorder characterized by a deficiency of the factor VIII complex: VIII: C, vWF:Ag, vWF:RCoF. The clinical features of this disease are spontaneous bleeding and mucosal or cutaneous bleeding following minimal injuries. The authors describe a case of a 4-year girl with recurrent episodes of gastrointestinal bleeding due to von Willebrand disease.
Subject(s)
Gastrointestinal Hemorrhage/diagnosis , von Willebrand Diseases/diagnosis , Child, Preschool , Duodenal Ulcer/complications , Duodenal Ulcer/diagnosis , Female , Gastrointestinal Hemorrhage/etiology , Humans , von Willebrand Diseases/complicationsABSTRACT
A cross section study was performed on 1342 children living in the Turin district to examine the modalities followed for milk-feeding during the first year of life. Children examined had been admitted to the infants' ward of the Pediatric University Clinic of Turin suffering from common illness of early infancy. Mothers were asked to fill in a questionnaire concerning breast-feeding, formula feeding and cow's milk feeding. Data collected show that 75% of infants were exclusively breast-fed at birth, that a large number of infants are already fed cow's milk after the 3rd month of life, that hypoallergenic formulas are overused (18.5% among adapted formulas), and that follow-up formulas are underused. Most of the mothers (74%) say that their dietary choices were made by their physician. These data indicate that infant dietary trends in our district are often not in accordance with scientific recommendations.
Subject(s)
Breast Feeding/statistics & numerical data , Food, Formulated/statistics & numerical data , Infant Food/statistics & numerical data , Milk/statistics & numerical data , Animals , Health Surveys , Humans , Infant , Infant Nutritional Physiological Phenomena , Italy/epidemiology , Mothers , Surveys and QuestionnairesABSTRACT
A cross section study was performed on 1060 healthy children living in the Torino district to examine the modalities followed for weaning during infancy. Mothers were asked to fill in a questionnaire which contained questions concerning the family, allergic and metabolic diseases in relatives, type of food given to infants before, during and after weaning, and source of dietary counselling. A score was given for each answer. Data indicate generally correct trends though major fields of error concerns prevention of food allergy and coeliac disease. Scores were correlated with family type and area of origin of the family.
Subject(s)
Infant Nutritional Physiological Phenomena , Weaning , Age Factors , Cross-Sectional Studies , Educational Status , Family , Family Health , Female , Food Hypersensitivity/prevention & control , Health Surveys , Humans , Infant , Infant, Newborn , Italy , Maternal Behavior , Mothers , Surveys and QuestionnairesABSTRACT
During the last years the Department of Earth Sciences, University of Roma "La Sapienza" carried out research activities in the field of both earthquake and volcanic geochemical premonitory events, in cooperation with the Gruppo Nazionale di Vulcanologia and the Istituto Nazionale di Geofisica. Interesting and new results were obtained as regards i)the geochemical processes accompanying earthquakes and volcanic crisis, and ii) technological and informatic approach in monitoring geochemical parameters. In particular were collected new factual evidences indicating that PCO2 seems to be the basic geochemical precess happening in correspondance with seismic and volcanic crises. In the paper a discussion on these points will be submitted to the attention of colleagues.(AU)
Subject(s)
Earthquakes , Volcanic Eruptions , Research , Italy , Causality , GeologyABSTRACT
A systematic survey on the distribution of geochemically and texicologically relevant trace elements in the soils of Italy was carried out on 32 soil profiles, developed in different environmental and pedological conditions. The aim of this study was to collect basic information on the background levels of trace elements, their geochemical behaviour and the relationships between weathering and pedogenetic processes. The statistically processed analytical results led to the following conclusions: (i) Trace element distribution in the profiles studied is consistent with pedochemical behaviour and rock lithology. A comparison with the world soil means shows that there are no significant differences, except for those elements largely utilised in agriculture (Cu, Zn) or, because of pollution, (Pd, Cd), or natural accumulation (Ni, Cr); (ii) data processing by cluster analysis shows marked correlations between some elements, for example, Al-V, Ni-Cr, Mn-Co. Groups of geochemically homogeneous samples, which correspond to the great soil families characteristic of each pedological landscape, are also indicated; (iii) evidence of soil contamination is provided by the high levels of some elements, especially in the A horizon. Cu and Zn seem to be concentrated in the Ap horizon of cultivated soils, while Pd and Cd may be derived from the atmosphere.
