1.
Food Chem Toxicol
; 23(4-5): 419-28, 1985.
Article
in English
| MEDLINE
| ID: mdl-4040093
ABSTRACT
The most abundant polar impurities detected by ion-pair high-pressure liquid chromatography of sodium saccharin produced by the Maumee process were identified as 5- and 6-aminosaccharin. The combined levels of these compounds in the samples analysed ranged from 99 to 152 mg/kg. Other less abundant polar impurities identified in Maumee process sodium saccharin were 7-aminosaccharin and o-sulphamoylbenzoic acid. Mutagenicity assays of 5-aminosaccharin, 6-aminosaccharin and a polar impurity fraction isolated from Maumee saccharin, gave negative results.
Subject(s)
Drug Contamination , Saccharin/analogs & derivatives , Saccharin/analysis , Chromatography, High Pressure Liquid , Magnetic Resonance Spectroscopy , Mutagens/analysis
2.
J Agric Food Chem
; 30(3): 600-2, 1982.
Article
in English
| MEDLINE
| ID: mdl-7096813