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Mult Scler Relat Disord ; 50: 102838, 2021 May.
Article in English | MEDLINE | ID: mdl-33609925

ABSTRACT

There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.


Subject(s)
Chickenpox , Herpes Zoster , Retinal Necrosis Syndrome, Acute , Central Nervous System , Herpes Zoster/complications , Herpes Zoster/drug therapy , Humans , Natalizumab/adverse effects , Retinal Necrosis Syndrome, Acute/chemically induced , Retinal Necrosis Syndrome, Acute/drug therapy
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