Subject(s)
Heart Rate/drug effects , Snake Venoms/pharmacology , Animals , Electrocardiography , Heart/drug effects , Male , MiceABSTRACT
Compound action potentials recorded from normal and M. leprae infected mice sciatic nerves were analysed in frequency domain using Fourier Series Analysis. Changes in myelinated fibre potentials were detected as early as 2nd post-inoculation month. This technique could be further developed to aid in early diagnosis of leprosy.
Subject(s)
Leprosy/physiopathology , Sciatic Nerve/physiopathology , Action Potentials , Animals , Computers , Female , Fourier Analysis , Mice , Mycobacterium leprae , SoftwareSubject(s)
Fetal Distress/diagnosis , Fetal Monitoring/methods , Female , Heart Rate , Humans , PregnancyABSTRACT
A study of the sciatic nerve compound action potential was carried out, in normal and non-immunosuppressed swiss mice (white) inoculated with 5000 M. leprae in each hind foot pad, from 1st to 7th post-inoculation month. In normal mice, the threshold for stimulation, maximum amplitude, duration and conduction velocity of all the three components of the compound action potential were measured. Progressive changes were noted in amplitude and the threshold for stimulations of the unmyelinated fibre ('C' fibres) potentials. These changes were compared with the changes observed in the myelinated fibre potentials.
